Cortical porosity of the mandible in an osteoporotic sheep model.
Cortical porosity of the mandible in an osteoporotic sheep model.
复制标题
骨质疏松绵羊模型中下颌骨的皮质孔隙度。
DOI：
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复制
发表时间：
2011
影响因子：
4.3
通讯作者：
R. Gruber
中科院分区：
文献类型：
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作者：
G. Dvorak;K. Reich;S. Tangl;J. Goldhahn;R. Haas;R. Gruber
目标
皮质孔隙度以及轴骨和附肢骨骼的厚度是骨质疏松性骨折的预测因素。然而，在颌骨中，皮质孔隙率和厚度可能会影响牙种植体的机械稳定性。我们之前已经表明，骨质疏松绵羊的颌骨的小梁结构受损，但分解代谢骨转换是否也导致皮质骨孔隙率仍然未知。
材料和方法
我们将六只接受卵巢切除、钙/维生素 D 限制和甲基泼尼松龙给药的老年羊的下颌骨与六只健康成年对照羊的下颌骨进行了比较。从纵裂、第一和第二前磨牙以及后磨牙区域制备组织学地面切片。通过组织形态计量学评估皮质孔隙度和厚度。
结果
骨质疏松绵羊的纵裂以及第一和第二前磨牙区域的皮质孔隙率高于成年对照。在磨牙后区域，差异未能达到显着性水平。当组织形态测量仅限于下颌皮质内毫米时，这种变化甚至更加突出。相反，骨质疏松症的诱导对皮质厚度没有明显的影响。
结论
这些结果表明，老年骨质疏松绵羊的下颌骨皮质孔隙度比成年对照羊更明显。
OBJECTIVES
Cortical porosity and thickness of the axial and the appendicular skeleton are predictors of osteoporotic fractures. In the jawbone, however, cortical porosity and thickness may affect the mechanical stability of dental implants. We have shown previously that the jawbone of osteoporotic sheep has impaired trabecular structures, but whether catabolic bone turnover also accounts for the cortical bone porosity remains unknown.
MATERIAL AND METHODS
We compared mandibular bone from six geriatric sheep subjected to ovariectomy, calcium/vitamin D restriction, and methylprednisolone administration to those of six healthy adult control sheep. Histological ground sections were prepared from the diastema, first and second premolars, and postmolar region. Cortical porosity and thickness were assessed by histomorphometry.
RESULTS
Cortical porosity was higher in osteoporotic sheep than in adult controls in the diastema and in the first and second premolar region. In the postmolar region, the difference failed to reach the level of significance. The changes were even more prominent when histomorphometry was restricted to the inner millimeter of the mandibular cortex. In contrast, induction of osteoporosis did not have a discernable effect on cortical thickness.
CONCLUSION
These results demonstrate that cortical porosity of mandibles is more pronounced in geriatric osteoporotic sheep than in adult controls.