Frontal brain activation in anxious school children
Frontal brain activation in anxious school children
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DOI：
10.1111/1469-7610.00019
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发表时间：
2002-02-01
期刊：
影响因子：
--
通讯作者：
Schmidt, MH
中科院分区：
文献类型：
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作者：
Baving, L;Laucht, M;Schmidt, MH
背景：在患有情绪障碍的婴儿和成人中发现了额叶脑激活的非典型EEG模式。对82名8岁儿童和56名1岁儿童进行了下列问题的检查：1.被诊断患有焦虑症的儿童是否表现出非典型的额叶脑激活模式？2.这种模式在不同年龄段的孩子身上也能表现出来吗？和3.在这些模式中是否存在与成人中所表现出的相似的性别差异？对基线脑电活动进行功率谱分析。结果如下：在8岁和11岁的焦虑女孩中，出现了众所周知的右额叶激活大于左额叶激活的模式，这在以前的内化学龄前儿童中已经发现。健康的女孩在8岁时没有表现出额叶不对称，在11岁时左额叶比右额叶更活跃。相比之下，健康的男孩表现出显着更大的右比左额叶激活，而焦虑的男孩显示没有额叶不对称的8岁，和更大的左比右额叶激活的11岁。结论：患有焦虑症的儿童表现出显着不同的模式额叶脑激活比健康的儿童没有任何终身诊断的精神障碍。焦虑儿童和健康儿童的额叶激活存在明显的性别差异。这可以在两个不同年龄的样本中得到证明。
Background: An atypical EEG pattern of frontal brain activation has been found in infants and adults with emotional disorders. Eighty-two 8-year-old children and 56 1 I-year-old children were examined with regard to the following questions: 1. Do children who are diagnosed with anxiety disorder exhibit an atypical pattern of frontal brain activation? 2. Can this pattern be demonstrated in children of different ages? and 3. Are there gender differences in these patterns similar to those that have been demonstrated in adults? Baseline EEG activity was subjected to power spectral analysis. Results: In 8- and 11-year-old anxious girls, the well-known pattern of greater right than left frontal activation emerged that has been found previously in internalizing preschoolers. Healthy girls showed no frontal asymmetry at 8 years of age, and a greater left than right frontal brain activation at 11 years. In contrast, healthy boys demonstrated a significantly greater right than left frontal activation, whereas anxious boys displayed no frontal asymmetry at the age of 8, and a greater left than right frontal activation at the age of 11. Conclusions: Children suffering from anxiety disorders exhibited a significantly different pattern of frontal brain activation than healthy children without any lifetime diagnosis of mental disorder. Distinct gender differences in frontal activation were found in anxious as well as in healthy children. This could be demonstrated in two samples of different ages.