A MODEL FOR CALCULATING TUMOR-CONTROL PROBABILITY IN RADIOTHERAPY INCLUDING THE EFFECTS OF INHOMOGENEOUS DISTRIBUTIONS OF DOSE AND CLONOGENIC CELL-DENSITY
A MODEL FOR CALCULATING TUMOR-CONTROL PROBABILITY IN RADIOTHERAPY INCLUDING THE EFFECTS OF INHOMOGENEOUS DISTRIBUTIONS OF DOSE AND CLONOGENIC CELL-DENSITY
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DOI：
10.1088/0031-9155/38/6/001
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发表时间：
1993-06-01
影响因子：
3.5
通讯作者：
NAHUM, AE
中科院分区：
文献类型：
--
作者：
WEBB, S;NAHUM, AE
辐射对肿瘤生物学效应的大多数计算假定克隆细胞密度是均匀的，即使考虑了不均匀的剂量分布。在实践中，肿瘤几乎肯定会有不均匀的克隆细胞密度。本文扩展了一种特殊的肿瘤控制概率模型，加入了可变的克隆性细胞密度，同时假定在整个治疗过程中，固定的2Gy射线分割大小和均匀的放射敏感性。由于几乎没有关于密度变化的活体数据，我们考虑了一些模型情况。一个明确的结论是，如果不降低tcp，肿瘤边缘克隆细胞密度的大幅降低将仅允许非常温和的剂量减少。一般来说，对Tcp的影响是剂量和克隆形成细胞密度变化的复杂函数。我们给出了使两者都能被包括在内的方程。
Most calculations of the biological effect of radiation on tumours assume that the clonogenic cell density is uniform even if account is taken of non-uniform dose distribution. In practice tumours will almost certainly have a non-uniform clonogenic cell density. This paper extends one particular model of tumour control probability (TCP) to incorporate a variable clonogenic cell density while at the same time assuming a constant 2 Gy fraction size and a uniform radiosensitivity throughout the treatment. Since there are virtually no in vivo data on the variation of density we consider some model situations. One clear conclusion is that a large reduction in clonogenic cell density at the edges of a tumour would permit only a very modest decrease in dose if the TCP is not to be reduced. In general the effect on TCP is a complicated function of the variation in both dose and clonogenic cell density. We give the equations which enable both to be included.