Cyclophospholipids Increase Protocellular Stability to Metal Ions
Cyclophospholipids Increase Protocellular Stability to Metal Ions
复制标题
DOI：
10.1002/smll.201903381
复制
发表时间：
2019-09-15
期刊：
影响因子：
13.3
通讯作者：
Mansy, Sheref S.
中科院分区：
文献类型：
--
作者：
Toparlak, O. Duhan;Karki, Megha;Mansy, Sheref S.
模型原细胞长期以来一直是用脂肪酸构建的，因为这些脂质在生物学上是合理的，至少在理论上可以支持原细胞的生命周期。然而，脂肪酸原细胞仅在狭窄的pH和金属离子浓度范围内稳定。这种不稳定性是特别成问题的，因为早期的地球会有一系列的条件，现存的生命完全依赖于金属离子的催化和生物聚合物的折叠和活性。在这里，prebiotically合理的单酰基环磷脂显示形成稳健的囊泡，其在宽范围的pH和高浓度的Mg 2+、Ca 2+和Na+下存活。重要的是，对Mg2+和Ca2+的稳定性通过环境浓度的Na+的存在而提高。这些结果表明，环磷脂，或具有类似特征的脂质，可能在达尔文进化论的出现过程中发挥了核心作用。
Model protocells have long been constructed with fatty acids, because these lipids are prebiotically plausible and can, at least theoretically, support a protocell life cycle. However, fatty acid protocells are stable only within a narrow range of pH and metal ion concentration. This instability is particularly problematic as the early Earth would have had a range of conditions, and extant life is completely reliant on metal ions for catalysis and the folding and activity of biological polymers. Here, prebiotically plausible monoacyl cyclophospholipids are shown to form robust vesicles that survive a broad range of pH and high concentrations of Mg2+, Ca2+, and Na+. Importantly, stability to Mg2+ and Ca2+ is improved by the presence of environmental concentrations of Na+. These results suggest that cyclophospholipids, or lipids with similar characteristics, may have played a central role during the emergence of Darwinian evolution.