Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation
Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation
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DOI：
10.1177/154405910608500606
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发表时间：
2006-06-01
影响因子：
7.6
通讯作者：
Graves, D. T.
中科院分区：
文献类型：
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作者：
Liu, R.;Bal, H. S.;Graves, D. T.
在2型Zucker糖尿病肥胖（ZDF）大鼠和血糖正常的同窝仔中使用结扎诱导的模型，我们研究了糖尿病是否主要通过增加骨丢失或限制骨修复来影响牙周炎。糖尿病组炎性细胞浸润的强度和持续时间明显增加（P < 0.05）。结扎7 d后破骨细胞形成和骨质侵蚀率与结扎组相似，而结扎解除4d后2型糖尿病组破骨细胞数量和活性明显高于结扎组（P < 0.05）。正常血糖大鼠骨吸收后新骨形成量是糖尿病大鼠的2.4- 2.9倍（P < 0.05）。糖尿病组骨衬细胞、成骨细胞和牙周膜成纤维细胞凋亡率明显升高，凋亡率明显降低（P < 0.05）。因此，糖尿病引起更持久的炎症反应，更大的附着丧失和更多的牙槽骨吸收，并损害新骨形成。后者可能受到骨衬里和PDL细胞凋亡增加的影响。
Using a ligature-induced model in type-2 Zucker diabetic fatty (ZDF) rat and normoglycemic littermates, we investigated whether diabetes primarily affects periodontitis by enhancing bone loss or by limiting osseous repair. Diabetes increased the intensity and duration of the inflammatory infiltrate (P < 0.05). The formation of osteoclasts and percent eroded bone after 7 days of ligature placement was similar, while four days after removal of ligatures, the type 2 diabetic group had significantly higher osteoclast numbers and activity (P < 0.05). The amount of new bone formation following resorption was 2.4- to 2.9-fold higher in normoglycemic vs. diabetic rats (P < 0.05). Diabetes also increased apoptosis and decreased the number of bone-lining cells, osteoblasts, and periodontal ligament fibroblasts (P < 0.05). Thus, diabetes caused a more persistent inflammatory response, greater loss of attachment and more alveolar bone resorption, and impaired new bone formation. The latter may be affected by increased apoptosis of bone-lining and PDL cells.