A new Co(III)-hypocrellin B complex with enhanced photonuclease activity.
A new Co(III)-hypocrellin B complex with enhanced photonuclease activity.
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DOI：
10.1016/j.jinorgbio.2011.03.021
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发表时间：
2011-07
影响因子：
3.9
通讯作者：
Yi Sun;Yuan-jun Hou;Qian-Xiong Zhou;Jingrong Chen;Bao-wen Zhang;Xuesong Wang
中科院分区：
文献类型：
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作者：
Yi Sun;Yuan-jun Hou;Qian-Xiong Zhou;Jingrong Chen;Bao-wen Zhang;Xuesong Wang
竹红菌素B（HB）是一种天然光敏剂，作为一种有前途的光动力学治疗（PDT）药物已被广泛而深入地研究。本工作以HB为桥连配体，TMP为末端配体，设计并合成了一种新的Co（III）配合物[Co2（HB）（TMP）4]4+（TMP = 3，4，7，8-四甲基-1，10-菲咯啉）。相对于HB，[Co2 HB（tmp）4]4+表现出改善的水溶性、在光疗窗口中增强的吸收率、增加的结合亲和力和对dsDNA的DNA光切割能力。[Co2（HB）（tmp）4]4+的光动力学活性来源于其1 O2光敏化能力，而[Cu 2（HB）（tmp）2]2+则依赖于超氧阴离子自由基（O2-radical dot）和羟基自由基（·OH）来光裂解DNA，尽管两种配合物具有相似的电化学性质。讨论了[Co2（HB）（tmp）4]4+和[Cu 2（HB）（tmp）2]2+光动力学机理的显著差异。
Hypocrellin B (HB), a naturally occurring photosensitizer, has been extensively and intensively studied as a promising photodynamic therapy (PDT) agent. In this work, a new Co(III) complex [Co2(HB)(tmp)4]4+(tmp = 3,4,7,8-tetramethyl-1,10-phenanthroline) was designed and synthesized with HB as bridging ligand and tmp as terminal ligand. [Co2HB(tmp)4]4+exhibits improved water solubility, enhanced absorptivity in the phototherapeutic window, increased binding affinity and DNA photocleavage capability toward dsDNA with respect to HB. The photodynamic activity of [Co2(HB)(tmp)4]4+stems from its1O2photosensitization ability, in sharp contrast to [Cu2(HB)(tmp)2]2+which relies on superoxide anion radical (O2-radical dot) and hydroxyl radical (·OH) to photocleave DNA, though the both complexes possess similar electrochemical properties. The remarkable difference between the photodynamic mechanisms of [Co2(HB)(tmp)4]4+and [Cu2(HB)(tmp)2]2+was discussed in detail.