Tissue Engineering Strategies for Fetal Myelomeningocele Repair in Animal Models
Tissue Engineering Strategies for Fetal Myelomeningocele Repair in Animal Models
复制标题
动物模型中胎儿脊髓脊膜膨出修复的组织工程策略
作者：
Miho Watanabe;Aimee G. Kim;A. Flake
脊髓脊膜膨出（MMC）是脊柱裂最严重的形式，是一种常见的和毁灭性的畸形。二十多年的动物模型实验工作已经导致了用于修复MMC缺陷的开放式胎儿手术的发展和临床应用。这种方法提供了改善的神经功能结果，现在是一种临床选择，用于管理产前诊断的MMC在选定的患者。然而，MMC的产前治疗仍有进一步改进的机会。一种侵入性较小的方法将允许在妊娠早期应用，降低母体和胎儿的风险，并减少神经损伤的可能性。组织工程为MMC的产前治疗提供了一种现实且有吸引力的替代方法。本文综述了MMC组织工程的基本原理，解决了最近的实验进展，并描述了潜在的未来方向。
Myelomeningocele (MMC), the most severe form of spina bifida, is a common and devastating malformation. Over two decades of experimental work in animal models have led to the development and clinical application of open fetal surgery for the repair of the MMC defect. This approach offers improved neurofunctional outcomes and is now a clinical option for the management of prenatally diagnosed MMC in selected patients. However, there are still opportunities for further improvement in the prenatal treatment of MMC. A less invasive approach would allow for an application earlier in gestation, with a reduction in maternal and fetal risks and the potential for reduced neurological injury. Tissue engineering offers a realistic and appealing alternative approach for the prenatal treatment of MMC. This review discusses the rationale for tissue engineering in MMC, addresses recent experimental progress and describes potential future directions.