Microvascular dysfunction in healthy insulin-sensitive overweight individuals
Microvascular dysfunction in healthy insulin-sensitive overweight individuals
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DOI：
10.1097/hjh.0b013e328333d1fc
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发表时间：
2010-02-01
影响因子：
4.9
通讯作者：
Levy, Bernard I.
中科院分区：
文献类型：
--
作者：
Czernichow, Sebastien;Greenfield, Jerry R.;Levy, Bernard I.
背景肥胖与心血管疾病发病率增加有关。皮肤是一个独特的网站，允许简单，无创评估毛细血管密度和内皮功能。在本研究中，我们测量了一组血压正常的超重/肥胖非糖尿病个体和健康瘦对照者的皮肤毛细血管密度和内皮功能。（BMI 27.9 +/- 2.7 kg/m2，平均值+/- SD），血压和空腹血糖正常，130名瘦型（BMI 22.4 +/- 1.7 kg/m2）对照。我们使用视频显微镜来测量皮肤毛细血管密度在静息状态和静脉闭塞。进行激光多普勒血流测定，结合乙酰胆碱离子导入（内皮依赖性血管舒张）和皮肤加热（内皮非依赖性血管舒张）。静息毛细血管密度与BMI呈负相关（r =-0.130，P
Background Obesity is associated with increased cardiovascular morbidity. The skin is a unique site allowing simple, noninvasive assessment of capillary density and endothelial function. In the present study, we measured skin capillary density and endothelial function in a group of normotensive overweight/obese nondiabetic individuals and healthy lean controls.Methods and results We examined 120 relatively insulin-sensitive overweight individuals (BMI 27.9 +/- 2.7 kg/m(2), mean +/- SD) with normal blood pressure and fasting plasma glucose and 130 lean (BMI 22.4 +/- 1.7 kg/m(2)) controls. We used video microscopy to measure skin capillary density in the resting state and during venous occlusion. Laser Doppler flowmetry, combined with iontophoresis of acetylcholine (endothelial-dependent vasodilation) and following skin heating (endothelial-independent dilation), was performed. Resting capillary density was negatively correlated with BMI (r = -0.130, P