Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex
Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex
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DOI：
10.1073/pnas.0708927105
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发表时间：
2008-03-11
影响因子：
11.1
通讯作者：
Carleton, Alan
中科院分区：
文献类型：
--
作者：
Accolla, Riccardo;Carleton, Alan
初级感觉皮层根据刺激的特定感觉特征在空间地图上显著地组织起来。在传入(“自下而上”)感觉输入改变后，这些皮质图可以进行可塑性重排，例如外周损伤或被动感觉体验。然而，人们对“自上而下”因素对皮质可塑性的影响知之甚少。在这里，我们研究了内脏不适对味觉皮质(GC)味觉表征的影响。在活体光学成像中，我们发现，在甜味和愉悦刺激下诱导条件性厌恶味觉(CTA)会导致其皮质表征的可塑性重排，变得更类似于苦味表征和不愉快味觉表征。通过使用行为任务，我们发现享乐知觉的变化与GC中的MAP可塑性直接相关。事实上，在CTA灭绝后对这些动物的成像表明，甜蜜和痛苦的表现是不同的。总而言之，我们发现，精神萎靡的内部状态会导致与刺激享乐值的行为变化相关的大脑皮层的可塑性重塑。我们认为，GC不仅编码味觉通道、强度和记忆，而且扩展了它的综合性质，以处理刺激享乐值。
Primary sensory cortices are remarkably organized in spatial maps according to specific sensory features of the stimuli. These cortical maps can undergo plastic rearrangements after changes in afferent ("bottom-up") sensory inputs such as peripheral lesions or passive sensory experience. However, much less is known about the influence of "top-down" factors on cortical plasticity. Here, we studied the effect of a visceral malaise on taste representations in the gustatory cortex (GC). Using in vivo optical imaging, we showed that inducing conditioned taste aversion (CTA) to a sweet and pleasant stimulus induced plastic rearrangement of its cortical representation, becoming more similar to a bitter and unpleasant taste representation. Using a behavior task, we showed that changes in hedonic perception are directly related to the maps plasticity in the GC. Indeed imaging the animals after CTA extinction indicated that sweet and bitter representations were dissimilar. in conclusion, we showed that an internal state of malaise induces plastic reshaping in the GC associated to behavioral shift of the stimulus hedonic value. We propose that the GC not only encodes taste modality, intensity, and memory but extends its integrative properties to process also the stimulus hedonic value.