Polycystic ovary syndrome in patients with epilepsy: A study in 102 Chinese women
Polycystic ovary syndrome in patients with epilepsy: A study in 102 Chinese women
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癫痫患者多囊卵巢综合征：一项针对 102 名中国女性的研究
DOI：
10.1016/j.seizure.2012.08.001
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发表时间：
2012-11-01
影响因子：
3
通讯作者：
Ling, Shanhong
中科院分区：
文献类型：
--
作者：
Zhou, Jue-Qian;Zhou, Lie-Min;Ling, Shanhong
目的：多囊卵巢综合征（PCOS）的发病率增加的妇女癫痫（WWE），这似乎是不同的种族。本研究旨在了解中国WWE患者PCOS的发病率及危险因素。方法：对139例中国育龄WWE中的102例进行研究，其中32例接受丙戊酸（VPA）治疗，40例接受其他抗癫痫药物（aed）治疗，30例未接受aed治疗。多囊卵巢综合征被定义为具有以下两种或两种以上的症状：多囊卵巢、雄激素分泌过多、闭经或少omenorrhoa （a/ oligomenrhoa）。结果：56例（54.9%）患者中发现PCOS的一种或多种分离成分，其中29例（28.4%）为多囊卵巢，20例（19.6%）为a/少月经，7例（6.9%）为高雄激素症，13例（12.7%）为明确的PCOS。癫痫发作的平均年龄为13.8 +/- 6.5岁，低于无上述疾病的患者（16.9 +/- 8.6岁，p < 0.05）。VPA治疗增加了PCOS的发病率（11/32,34.4%），此外还增加了血液中睾酮和黄体生成素（LH）的水平以及LH与FSH（促卵泡激素）的比值。在这些WWE中，PCOS的发病率与癫痫发作的类型、持续时间或频率之间没有明显的关系。结论：中国WWE育龄期PCOS发病率增加，是普通人群的2倍以上。风险因素包括幼年癫痫发作和VPA治疗。(c) 2012英国癫痫协会。Elsevier Ltd.出版。版权所有。
Purpose: The incidence of polycystic ovary syndrome (PCOS) increases in women with epilepsy (WWE), which appears to vary with ethnicity. This study was conducted to determine the incidence and risk factors of PCOS in Chinese WWE.Methods: The study was carried out in 102 of 139 Chinese WWE at reproductive ages, with 32 receiving valproic acid (VPA), 40 receiving other antiepileptic drugs (AEDs), and 30 without AEDs therapy. PCOS was defined as having 2 Or more of the following components: polycystic ovaries, hyperandrogenism, and amenorrhoea or oligomenorrhoea (a/oligomenorrhoea).Results: One or more isolated components of PCOS were found in 56 (54.9%) patients, with 29 (28.4%) having polycystic ovaries, 20 (19.6%) with a/oligomenorrhea, 7 (6.9%) with hyperandrogenism, and 13 (12.7%) with defined PCOS. Their average age at the start of seizure was 13.8 +/- 6.5 years, younger than that of patients without these disorders (16.9 +/- 8.6 years, p < 0.05). VPA therapy increased the incidence of PCOS (11/32, 34.4%), in addition to increased blood levels of testosterone and luteinizing hormone (LH) as well as LH to FSH (follicle-stimulating hormone) ratio. No significant relationship was found between the incidence of PCOS and the type, duration, or frequency of seizures in these WWE.Conclusion: There is an increased incidence of PCOS in Chinese WWE at reproductive ages, by more than 2 times of that in the general population. Risk factors include seizures starting at a young age and VPA therapy. (c) 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.