Subclinical thyroid disorders: significance and clinical impact
Subclinical thyroid disorders: significance and clinical impact
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DOI：
10.1136/jcp.2008.057414
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发表时间：
2010-05-01
影响因子：
3.4
通讯作者：
Pearce, Simon H. S.
中科院分区：
文献类型：
--
作者：
Razvi, Salman;Weaver, Jolanta U.;Pearce, Simon H. S.
亚临床甲状腺疾病是指与正常甲状腺激素浓度相关的血清促甲状腺激素（TSH）水平异常。这些疾病的诊断取决于确定“正常”的甲状腺功能正常的TSH范围；在这篇综述中，总结了支持和反对降低TSH上限的论点。尽管亚临床甲状腺功能减退症和亚临床甲状腺功能亢进症经常出现，但由于许多观察性研究结果相互矛盾，它们的长期后果存在争议。描述了这两种亚临床疾病的病因、影响和治疗结果，并概述了在这些疾病方面未来研究的方向。
Subclinical thyroid diseases are defined by abnormal serum thyroid stimulating hormone (TSH) levels associated with normal thyroid hormone concentrations. The diagnosis of these conditions depends on defining the 'normal' euthyroid TSH range; in this review, arguments for and against lowering the upper limit of TSH are summarised. Although, subclinical hypothyroidism and subclinical hyperthyroidism are frequently encountered, their long-term consequences are debated due to conflicting results from many observational studies. The causes, effects and outcomes of treatment of both subclinical diseases are described, and the direction of future research in these conditions is outlined.