Expression of heat shock proteins in the developing rat retina
Expression of heat shock proteins in the developing rat retina
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DOI：
10.1016/0304-3940(96)12406-x
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发表时间：
1996-03-01
影响因子：
2.5
通讯作者：
Kikuchi, H
中科院分区：
文献类型：
--
作者：
Kojima, M;Hoshimaru, M;Kikuchi, H
采用Northern blot方法检测发育中的大鼠视网膜中热休克蛋白（HSPs）、HSP70、HSP90和免疫球蛋白重链结合蛋白（Bip）的表达。诱导型HSP70的表达在整个围产期保持一致的低水平，直到P5，在P7时迅速增加。另一方面，HSP70、HSP90和Bip的组成型在整个发育阶段均在大鼠视网膜中表达，除了P3-P5外，P3-P5的表达出现短暂性下降。诱导型HSP70 mRNA在P7的表达增加可能与视神经系统光接受功能的成熟相对应，可能是光刺激的应激反应之一。讨论了各热休克蛋白在大鼠视觉系统发育过程中的潜在作用。
Expression of three heat shock proteins (HSPs), HSP70, HSP90, and immunoglobulin heavy chain binding protein (Bip) was examined in the developing rat retina using Northern blot analysis. The expression of the inducible form of HSP70 remained uniformly low throughout the perinatal period until P5 and increased rapidly at P7. On the other hand, the constitutive form of HSP70, HSP90, and Bip were expressed constitutively in the rat retina throughout the developmental stage except P3-P5, at which a transient decrease of the expression was observed. The increase of inducible HSP70 mRNA at P7 may correspond to the functional maturation of photoreception in the visual nervous system and may be one of the stress responses to photostimulation. The potential roles of each HSP during development of the rat visual system are discussed.