REACTIONS OF ACETYLENIC KETONES WITH METHYL α‐NAPHTHYLACETATE. A SYNTHESIS OF 1‐AMINO‐2‐PYRIDONE DERIVATIVES
REACTIONS OF ACETYLENIC KETONES WITH METHYL α‐NAPHTHYLACETATE. A SYNTHESIS OF 1‐AMINO‐2‐PYRIDONE DERIVATIVES
复制标题
乙酰酮与 α-萘乙酸甲酯的反应合成 1-氨基-2-吡啶酮衍生物。
DOI：
10.1002/chin.197902194
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
H. Hamoud
中科院分区：
文献类型：
--
作者：
Y. Al;F. Al;N. El;H. Hamoud
在甲醇钠存在下，炔酮（Ia-f）与α-萘乙酸甲酯反应生成相应的6-芳基-3-α-萘基-4-苯基-2-吡喃酮（IIa-f），后者在乙醇中与水合肼反应生成相应的1-氨基-2-吡啶酮衍生物（VIa-f）。
产物的结构由化学和光谱证据确定。
Reactions of acetylenic ketones (Ia-f) with methyl α-naphthylacetate in the presence of sodium methoxide gave the corresponding 6-aryl-3-α-naphthyl-4-phenyl-2-pyrones (IIa-f) which upon refluxing with hydrazine hydrate in ethanol gave the corresponding 1-amino-2-pyridone derivatives (VIa-f).
The structure of the products was established by chemical and spectroscopic evidence.