COGNITIVE IMPAIRMENTS ASSOCIATED WITH EARLY PARKINSONS-DISEASE
COGNITIVE IMPAIRMENTS ASSOCIATED WITH EARLY PARKINSONS-DISEASE
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DOI：
10.1212/wnl.39.4.557
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发表时间：
1989-04-01
期刊：
影响因子：
9.9
通讯作者：
WEINER, WJ
中科院分区：
文献类型：
--
作者：
LEVIN, BE;LLABRE, MM;WEINER, WJ
我们对41名新近确诊的帕金森病患者和41名对照组进行了一系列认知测试，以评估与帕金森S病(PD)相关的早期神经心理变化。帕金森受试者在评估和选择语言和视觉空间测量的任务上做得和对照一样好。然而，帕金森病受试者在嵌入图形、面部识别、谚语以及言语和图形记忆测量上表现得明显较差，在设定的转移任务中做出了更坚持不懈的反应。谚语、镶嵌图形和记忆的测量的判别函数解释了组间差异的22%。这些数据表明，早期帕金森病的认知改变比最初描述的更普遍，可能反映了更广泛的病理过程的开始。
We administered a battery of cognitive tests to 41 recently diagnosed Parkinson patients and 41 controls to assess the early neuropsychological changes associated with Parkinson''s disease (PD). Parkinson subjects did as well as controls on tasks assessing and select language and visuospatial measures. However, PD subjects did significantly worse on embedded figures, facial recognition, proverbs, and verbal and figural memory measures, and made more perseverative responses on a set shifting task. A discriminant function of measures of proverbs, embedded figures, and memory accounted for 22% of the variance between groups. These data suggest that the cognitive changes in early PD are more pervasive than originally described and may reflect the onset of a more widespread pathologic process.