A unique subpopulation of CD4+ regulatory T cells controls wasting disease, IL-10 secretion and T cell homeostasis
A unique subpopulation of CD4+ regulatory T cells controls wasting disease, IL-10 secretion and T cell homeostasis
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DOI：
10.1002/eji.200324205
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发表时间：
2003-09-01
影响因子：
5.4
通讯作者：
Papiernik, M
中科院分区：
文献类型：
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作者：
Banz, A;Peixoto, A;Papiernik, M
CD25(+)CD4(+)调节性T细胞在控制免疫应答中发挥重要作用，并使用不同的调节机制。这些不同的活动可能是由不同的亚集介导的。在这里，我们显示CD103(+)CD25(+)CD4(+)T细胞(控制炎症性肠病)在肠道相关淋巴组织中高度浓缩，并具有独特的功能特性。在体内，只有这个亚群才能控制衰减性疾病和外周T细胞动态平衡。在体外，只有这个亚群能够调节IL-10的分泌，它也可能介导感染抑制。这些结果表明，调节性T细胞可以分为不同的亚群，它们具有明确的功能特性和调节机制。
CD25(+)CD4(+) regulatory T cells have major roles in controlling immune responses, and use heterogeneous regulatory mechanisms. It is possible that these different activities are mediated by different subsets. Here we show that CD103(+)CD25(+)CD4(+) T cells (that control inflammatory bowel disease) are highly enriched in gut-associated lymphoid tissue and have unique functional properties. In vivo, only this subpopulation is able to control wasting disease and peripheral T cell homeostasis. In vitro, only this subpopulation is able to regulate IL-10 secretion, and it might also mediate infectious suppression. These results demonstrate that regulatory T cells can be divided into discrete subpopulations with defined functional properties and regulatory mechanisms.