Endometriosis: where are we and where are we going?
Endometriosis: where are we and where are we going?
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DOI：
10.1530/rep-16-0052
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Burns KA
中科院分区：
文献类型：
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作者：
Greene AD;Lang SA;Kendziorski JA;Sroga-Rios JM;Herzog TJ;Burns KA
子宫内膜异位症目前影响着美国1550万育龄妇女，其症状包括疼痛期（痛经）、慢性盆腔疼痛、性交疼痛（性交困难）和不孕症。它被定义为子宫腔外存在子宫内膜组织，并发现主要附着在腹膜腔内的部位。子宫内膜异位症的诊断仅通过手术进行，因为不存在用于疾病诊断的一致生物标志物。子宫内膜异位症没有治愈方法，治疗仅针对症状，而不是疾病的潜在机制。子宫内膜异位症患者的子宫内膜、免疫系统和/或腹膜腔的个体易感因素或固有缺陷的性质尚不清楚。过去5年（2010-2015）的文献促进了我们对激素、激素受体、免疫失调、激素治疗以及子宫内膜异位症向卵巢癌转化的关键知识。在这篇综述中，我们涵盖了上述主题，旨在为读者提供进一步研究的概述和相关参考，以突出子宫内膜异位症研究取得的进展，同时总结急需的子宫内膜异位症研究的关键领域。
Endometriosis currently affects ∼5.5 million reproductive-aged women in the U.S. with symptoms such as painful periods (dysmenorrhea), chronic pelvic pain, pain with intercourse (dyspareunia), and infertility. It is defined as the presence of endometrial tissue outside the uterine cavity and is found predominately attached to sites within the peritoneal cavity. Diagnosis for endometriosis is solely made through surgery as no consistent biomarkers for disease diagnosis exist. There is no cure for endometriosis and treatments only target symptoms and not the underlying mechanism(s) of disease. The nature of individual predisposing factors or inherent defects in the endometrium, immune system, and/or peritoneal cavity of women with endometriosis remains unclear. The literature over the last 5 years (2010-2015) has advanced our critical knowledge related to hormones, hormone receptors, immune dysregulation, hormonal treatments, and the transformation of endometriosis to ovarian cancer. In this review, we cover the aforementioned topics with the goal of providing the reader an overview and related references for further study to highlight the progress made in endometriosis research, while concluding with critical areas of endometriosis research that are urgently needed.