Intoxication Delirium following Use of Synthetic Cathinone Derivatives
Intoxication Delirium following Use of Synthetic Cathinone Derivatives
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DOI：
10.3109/00952990.2012.694535
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发表时间：
2012-11-01
影响因子：
2.7
通讯作者：
Vilensky, Dmitry A.
中科院分区：
文献类型：
--
作者：
Penders, Thomas M.;Gestring, Richard E.;Vilensky, Dmitry A.
背景资料：在已发表的使用“浴盐”后出现幻觉性谵妄的报告中，分析实验室测试证明了合成卡西酮衍生物亚甲二氧基吡咯戊酮（MDPV）。MDPV可导致苯环利定（PCP）筛查免疫测定结果假阳性。使用MDPV的患者容易发生兴奋性谵妄综合征（ExD），这也是PCP的一种情况。目的：本综述总结了几个系列病例的谵妄与MDPV强调中毒和兴奋性谵妄的特点。方法：对来自东北卡罗来纳州的一系列患者进行文献回顾和临床描述。结论：MDPV很可能是过去两年在美国娱乐性使用“浴盐”引起的毒性和兴奋性谵妄综合征的负责因子。科学意义：使用MDPV的患者容易发生毒性谵妄，并伴有一些ExD。与严重医学疾病的相当大风险相关的病症。针对极端激动和偏执的常用干预措施可能会加剧ExD的病理生理学。
Background: In published reports of hallucinatory delirium following use of "bath salts" analytic laboratory testing has demonstrated the synthetic cathinone derivative methylenedioxypyrovalerone (MDPV). MDPV can cause a false-positive screening immunoassay result for phencyclidine (PCP). Patients using MDPV are prone to development of the syndrome of excited delirium (ExD), a condition also described with PCP. Objective: This review summarize reports from several series of cases of delirium associated with MDPV emphasizing the features of both intoxication and excited delirium. Methods: Literature review and clinical description of a series of patients from Eastern North Carolina. Conclusion: MDPV is likely the responsible agent in production of both toxic and excited delirium syndromes identified with the recreational use of "bath salts" in the United States over the past two years. Scientific significance: Patients using MDPV are prone to the development of toxic delirum with some developing ExD. a condition associated with considerable risk for serious medical morbidity. Commonly used interventions directed at extreme agitation and paranoia may exacerbate the pathophysiology of ExD.