Effects of diesel exhaust particles on human neutrophil activation
Effects of diesel exhaust particles on human neutrophil activation
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DOI：
10.1080/01902140601047641
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发表时间：
2006-10-01
影响因子：
1.7
通讯作者：
Morishita, Tetsuo
中科院分区：
文献类型：
--
作者：
Matsuzaki, Tatsu;Amakawa, Kazuhisa;Morishita, Tetsuo
柴油废气颗粒(DEP)与呼吸系统疾病有关，暴露在柴油废气中会引起炎症反应，并伴随着明显的白细胞在肺内的渗透。这项研究检测了中性粒细胞是否被DEP的活性成分(DEP的甲醇提取物[Me-DEP])激活。结果表明，中性粒细胞经Me-DEP处理后，f-肌动蛋白含量增加，黏附分子表面表达增加，白细胞介素8和白三烯B4、超氧化物歧化酶和基质金属蛋白酶9的释放增加。因此，作者得出结论，接触DEP会激活中性粒细胞，这些激活的中性粒细胞可能与DEP相关的不良呼吸健康影响和慢性炎症性肺部疾病的发病机制有关。
Diesel exhaust particles (DEP) are associated with respiratory disease and exposure to diesel exhaust induces an inflammatory response associated with marked leukocytic infiltration in the lung. This study examined whether neutrophils are activated by the active component of DEP (methanol extract of DEP [me-DEP]). The authors demonstrated that neutrophils exposed to me-DEP had increased levels of the f-actin content, the surface expression of adhesion molecules, and the release of interleukin (IL-8) and leukotriene B4 (LTB4), superoxide, and matrix metalloproteinase (MMP-9). Thus, the author conclude that DEP exposure activates neutrophils and that these activated neutrophils could contribute to the adverse respiratory health effects associated with DEP and to the pathogenesis of chronic inflammatory lung diseases.