Compensatory changes in thyroid blood flow are only partially mediated by thyrotropin.
Compensatory changes in thyroid blood flow are only partially mediated by thyrotropin.
复制标题
甲状腺血流的代偿性变化仅部分由促甲状腺素介导。
DOI：
10.1152/ajpendo.1991.260.4.e608
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Hedge,GA
中科院分区：
文献类型：
--
作者：
Michalkiewicz,M;Connors,JM;Huffman,LJ;Pietrzyk,Z;Hedge,GA
它已被证明，甲状腺的代偿性生长和激素分泌的代偿性增加，发生在半甲状腺切除术后的甲状腺血流量（BF）的显着增加。甲状腺残留的这些变化可能是由于血浆促甲状腺激素（TSH）浓度的同时增加。然而，有人认为甲状腺的代偿性生长也可能涉及神经反射。在这项研究中，我们探讨了甲状腺次全切除术后TSH在介导甲状腺BF和质量代偿性改变中的作用。用乙醚麻醉雄性Sprague-Dawley大鼠进行手术或假半甲状腺切除术。一半的hemithyroidectomized大鼠（HTX）没有接受进一步的治疗，在另一半的HTX大鼠（钳），血浆TSH水平维持在与那些在假手术动物的水平，开始在hemithyroidectomy时开始不断的甲状腺激素替代。术后2、7、14和21天采集血浆样本，进行TSH、3，5，3 '-三碘甲状腺原氨酸和甲状腺素放射免疫测定。在术后1、2和3周通过放射性微球技术（141 Ce，15微米直径）的参考样品版本测定甲状腺BF。血浆TSH水平和甲状腺叶的重量显着升高HTX大鼠，但在钳夹大鼠。甲状腺BF在HTX大鼠中显著增加。甲状腺BF也显着增加，尽管抑制血浆TSH浓度的上升，在钳夹大鼠，但这种增加是小于在HTX大鼠。半甲状腺切除术和Clamp治疗对动脉血压或其他组织的BF都没有任何影响（例如，肾）。（250字处删节）
It has been shown that the compensatory growth of the thyroid gland and the compensatory increase in hormone secretion that occur after hemithyroidectomy are preceded by a dramatic increase in thyroid blood flow (BF). These alterations in the thyroid remnant may be due to the concomitant increase in plasma thyrotropin (TSH) concentrations. It has been suggested, however, that the compensatory thyroid growth may also involve a neural reflex. In this study we have investigated the role of TSH in mediating the compensatory alterations in thyroid BF and mass after subtotal thyroidectomy. Male Sprague-Dawley rats were anesthetized with ether for surgical or sham hemithyroidectomy. One-half of the hemithyroidectomized rats (HTX) received no further treatment; in the other one-half of the HTX rats (Clamp), plasma TSH levels were maintained at levels comparable with those in sham-operated animals by initiating constant thyroid hormone replacement beginning at the time of hemithyroidectomy. Plasma samples for TSH, 3,5,3'-triiodothyronine, and thyroxine radioimmunoassays were obtained 2, 7, 14, and 21 days after surgery. Thyroid BF was determined at 1, 2, and 3 wk after surgery by the reference sample version of the radioactive microsphere technique (141Ce, 15 microns diameter). Plasma TSH levels and thyroid lobe weight were significantly elevated in HTX rats but not in Clamp rats. Thyroid BF was markedly increased in HTX rats. Thyroid BF was also significantly increased in Clamp rats despite the suppression of the rise in plasma TSH concentration, but this increase was less than that in HTX rats. Neither hemithyroidectomy nor Clamp treatments had any effect on arterial blood pressure or BF to other tissues (e.g., kidney).(ABSTRACT TRUNCATED AT 250 WORDS)