Plasma nortriptyline and clinical response in depression.
Plasma nortriptyline and clinical response in depression.
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血浆去甲替林和抑郁症的临床反应。
DOI：
10.1016/0165-0327(85)90034-5
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发表时间：
1985
影响因子：
6.6
通讯作者：
Wetzel,RD
中科院分区：
文献类型：
--
作者：
Murphy,GE;Simons,AD;Wetzel,RD
据报道，去甲替林血药浓度低于50 ng/ml或高于150 ng/ml会产生低于中间水平的结果。在本研究中，无并发症的原发性非双相抑郁患者被随机分配到单独使用NT或认知疗法治疗12周。35名患者中有9名患者的血浆NT平均水平为50 ng/ml，其中5名患者的临床症状改善至汉密尔顿抑郁量表中⩽7的标准水平。这一改善率与平均血浆水平在假定治疗窗口内的患者没有任何不同。未检测到150 ng/ml的上限。这项研究的提出是希望重振显然处于休眠状态的抗抑郁药最佳治疗血浆水平的研究。
Plasma levels of nortriptyline below 50 ng/ml or above 150 ng/ml have been reported to yield results inferior to intermediate levels. In the present study, patients with uncomplicated primary, nonbipolar depression were randomly assigned to 12 weeks of treatment with NT alone or with cognitive therapy. Nine of 35 patients had mean NT plasma levels < 50 ng/ml. Five of them improved clinically to the criterion level of ⩽ 7 on the Hamilton Rating Scale for Depression. This improvement rate was not at all different from that of patients with mean plasma levels within the presumed therapeutic window. The upper limit of 150 ng/ml was not tested. This study is presented in the hope of reviving the apparently dormant search for optimal therapeutic plasma levels of antidepressants.