Aryl hydrocarbon receptor: Linking environment to immunity.
Aryl hydrocarbon receptor: Linking environment to immunity.
复制标题
DOI：
10.1016/j.smim.2015.10.002
复制
发表时间：
2015-09
影响因子：
7.8
通讯作者：
Colonna M
中科院分区：
文献类型：
--
作者：
Cella M;Colonna M
粘液和屏障组织是独特的，因为它们介导宿主与周围环境之间的串扰，其中包含许多潜在的有害因素。因此，至关重要的是，屏障和粘膜表面上存在的细胞类型配备有感知环境变化并相应地校准其响应的机制。芳烃受体（Aryl Hydrocarbon Receptor，AHR）是一种配体依赖性转录因子，对环境污染物如苯并芘和卤代二恶英产生生物学应答。令人惊讶的是，在过去的几年中，大量的证据表明，AHR也参与维持稳态或通过调节屏障和粘膜界面处的关键细胞类型的生物学反应而触发病理学。在这里，我们将回顾这一领域的进展，并讨论靶向AHR激活如何影响疾病。
Mucosal and barrier tissues are unique in that they mediate crosstalk between the host and the surrounding environment, which contains many potentially harmful factors. Therefore, it is critical that cell types present at barrier and mucosal surfaces are equipped with mechanisms to sense changes in the environment and to calibrate their responses accordingly. Aryl Hydrocarbon Receptor (AHR) is a ligand dependent transcription factor well known to generate biological responses to environmental pollutants, such as benzo{a}pyrene and halogenated dioxins. Surprisingly, in the last few years a large body of evidence has shown that AHR is also involved in maintaining homeostasis or in triggering pathology by modulating the biological responses of critical cell types at the barrier and mucosal interfaces. Here, we will review progresses in this field and discuss how targeting AHR activation may impact disease.