The Interaction Between Medical Burden and Anticholinergic Cognitive Burden on Neuropsychological Function in a Geriatric Primary Care Sample
The Interaction Between Medical Burden and Anticholinergic Cognitive Burden on Neuropsychological Function in a Geriatric Primary Care Sample
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DOI：
10.1093/arclin/acu073
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发表时间：
2015-03-01
影响因子：
2.6
通讯作者：
Duff, Kevin
中科院分区：
文献类型：
--
作者：
Block, Cady K.;Logue, Erin;Duff, Kevin
神经心理功能受损与医疗负担（MB）增加和使用更多抗胆碱能药物有关。然而，MB和抗胆碱能认知负荷（AB）之间的相互作用对神经心理性能是未知的。在290名老年初级保健患者的样本中，AB水平较高的患者在神经心理状态评估可重复组合（RBANS）中表现出较差的总指数表现。此外，还注意到相互作用效应，即MB较少的参与者对RBANS总、注意力和延迟记忆指数评分有更大的抗胆碱能作用。无论AB水平如何，MB较多的参与者表现较差。这些结果表明，MB的影响可能被老年患者的抗胆碱能作用所掩盖。
Poorer neuropsychological function is associated with increased medical burden (MB) and the use of more anticholinergic medications. However, the interaction between MB and anticholinergic cognitive burden (AB) on neuropsychological performance is unknown. In a sample of 290 elderly primary care patients, those with a greater level of AB demonstrated poorer Total Index performance on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Further, an interaction effect was noted such that there was a greater anticholinergic effect on RBANS Total, Attention, and Delayed Memory Index scores for participants with fewer MB. Participants with more MB demonstrated poorer performance irrespective of their level of AB. These results indicate that MB effects may be overshadowed by anticholinergic effects in older patients.