Is absolute noninvasive temperature measurement by the Pr[MOE-DO3A] complex feasible
Is absolute noninvasive temperature measurement by the Pr[MOE-DO3A] complex feasible
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Pr[MOE-DO3A]复合物绝对无创温度测量是否可行
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
R. Felix
中科院分区：
文献类型：
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作者：
M. Hentschel;M. Findeisen;W. Schmidt;Thomas Frenzel;W. Wlodarczyk;P. Wust;R. Felix
最近，10-（2-甲氧基乙基）-1，4，7，10-四氮杂-环十二烷-1，4，7-三乙酸酯（Pr[MOE-DO 3A]）的镨配合物通过1H光谱用于非侵入式温度测量的可行性已经被证明。特别地，已经显示了复合物对于非侵入性温度测量的适用性，包括没有空间分辨率的体内光谱以及在低时间分辨率（≥4 min）和高时间分辨率（屏气，20 s）下的第一光谱成像测量。到目前为止，根据特定实验条件的校准曲线是必要的。这项工作的目的是澄清是否Pr[MOE-DO 3A]探针结合1H-NMR光谱允许非侵入性的绝对温度测量具有高精度。两种不同代表性介质（蒸馏水和人血浆）的测量结果显示，校准曲线对周围介质的依赖性轻微但显著。在水和等离子体中导出了Pr[MOE-DO 3A]的OCH 3和水之间的化学位移差（F）的温度依赖性的校准曲线，F =−（27.53±0.04）+（0.125±0.001）*T和F =−（27.61±0.02）+（0.129±0.001）*T。F单位为ppm，T单位为°C。然而，即使对于0.001 ppm/pt的最高光谱分辨率，差异也是微小的，因此在实际条件下它们是不可区分的。水的温度误差估计为±0.18°C，血浆的温度误差估计为±0.14°C，仅略差于光纤温度探头的测量精度（±0.1°C）。可以得出结论，所获得的结果表明1H光谱法结合Pr[MOE-DO 3A]探针用于绝对温度测量的可行性，最大精度为±0.2°C。
Recently, the feasibility of the praseodymium complex of 10-(2-methoxyethyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetate (Pr[MOE-DO3A]) for non-invasive temperature measurement via1H spectroscopy has been demonstrated. Particularly the suitability of the complex for non-invasive temperature measurements including in vivo spectroscopy without spatial resolution as well as first spectroscopic imaging measurements at low temporal resolution (≥4 min) and high temporal resolution (breath hold, ∼20 s) has been shown. As of today, calibration curves according to the particular experimental conditions are necessary. This work aims to clarify whether the Pr[MOE-DO3A] probe in conjunction with1H-NMR spectroscopy allows non-invasive absolute temperature measurements with high accuracy. The measurement results from two different representative media, distilled water and human plasma, show a slight but significant dependence of the calibration curves on the surrounding medium. Calibration curves in water and plasma were derived for the temperature dependence of the chemical shift difference (F) between Pr[MOE-DO3A]'s OCH3 and water withF=−(27.53±0.04)+(0.125±0.001)*T andF=−(27.61±0.02)+(0.129±0.001)*T. respectivel, withF in ppm andT in °C. However, the differences are minuscule even for the highest spectral resolution of 0.001 ppm/pt, so that they are indistinguishable under practical conditions. The estimated temperature errors are ±0.18°C for water and ±0.14°C for plasma and with that only slightly worse than the measurement accuracy of the fiber-optical temperature probe (±0.1°C). It can be concluded that the results obtained indicate the feasibility of the1H spectroscopy method in conjunction with the Pr[MOE-DO3A] probe for absolute temperature measurements, with a maximum accuracy of ±0.2°C.
使用钴核磁共振测量动物模型中微波诱导的乳腺肿瘤加热。
DOI：
10.1006/jmrb.1996.0065
发表时间：
1996
期刊：
Journal of magnetic resonance. Series B.
影响因子：
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作者：
Webb,AG;Wiener,EC
通讯作者：
Wiener,EC
使用顺磁稀土配合物进行 NMR 温度测量。
DOI：
10.1006/jmre.1998.1429
发表时间：
1998
期刊：
Journal of magnetic resonance (San Diego, Calif. : 1997)
影响因子：
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作者：
Zuo,CS;Metz,KR;Sun,Y;Sherry,AD
通讯作者：
Sherry,AD