Basic concepts in population modeling, simulation, and model-based drug development-part 2: introduction to pharmacokinetic modeling methods.
Basic concepts in population modeling, simulation, and model-based drug development-part 2: introduction to pharmacokinetic modeling methods.
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DOI：
10.1038/psp.2013.14
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发表时间：
2013-04-17
影响因子：
3.5
通讯作者：
Upton, R N
中科院分区：
文献类型：
--
作者：
Mould, D R;Upton, R N
群体药代动力学模型用于描述患者药物暴露的时间过程，并研究患者暴露的变异性来源。它们可用于模拟替代剂量方案，以便在研究进行之前对剂量方案进行知情评估。本文是三部分系列中的第二部分，介绍了开发和评估群体药代动力学模型的方法。在线补充数据中提供了示例模型文件。CPT：Pharmacometrics & Systems Pharmacology（2013）2，e38; doi：10.1038/psp.2013.14; 2013年4月17日提前在线出版
Population pharmacokinetic models are used to describe the time course of drug exposure in patients and to investigate sources of variability in patient exposure. They can be used to simulate alternative dose regimens, allowing for informed assessment of dose regimens before study conduct. This paper is the second in a three‐part series, providing an introduction into methods for developing and evaluating population pharmacokinetic models. Example model files are available in theSupplementary Dataonline.CPT: Pharmacometrics & Systems Pharmacology(2013) 2, e38; doi:10.1038/psp.2013.14; advance online publication 17 April 2013