Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
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DOI：
10.1073/pnas.95.15.8991
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发表时间：
1998-07-21
影响因子：
11.1
通讯作者：
Beavo, JA
中科院分区：
文献类型：
--
作者：
Soderling, SH;Bayuga, SJ;Beavo, JA
环核苷酸磷酸二酯酶（PDE）通过将cAMP和cGMP水解成其相应的5'单磷酸来调节cAMP和cGMP的细胞内水平。本文报道了一种新的小鼠睾丸cAMP特异性磷酸二酯酶的克隆和鉴定，这种独特的磷酸二酯酶含有一个催化结构域，
Cyclic nucleotide phosphodiesterases (PDEs) regulate intracellular levels of cAMP and cGMP by hydrolyzing them to their corresponding 5' monophosphates. We report here the cloning and characterization of a novel cAMP-specific PDE from mouse testis, This unique phospho diesterase contains a catalytic domain that overall shares