IgE-mediated hypersensitivity and contact sensitivity to multiple environmental allergens in atopic dermatitis.
IgE-mediated hypersensitivity and contact sensitivity to multiple environmental allergens in atopic dermatitis.
复制标题
IgE 介导的特应性皮炎对多种环境过敏原的超敏反应和接触敏感性。
DOI：
10.1001/archderm.1994.01690110059007
复制
发表时间：
1994
影响因子：
--
通讯作者：
H. Tagami
中科院分区：
文献类型：
--
作者：
M. Tanaka;S. Aiba;N. Matsumura;H. Aoyama;N. Tabata;Y. Sekita;H. Tagami
背景和设计
特应性皮炎（AD）是一种慢性湿疹性皮肤病，发生于具有特应性素质的患者，其特征在于针对主要来源于其他活生物体的环境过敏原产生IgE抗体的倾向增加。在实验上，湿疹性皮肤损伤不能由IgE介导的直接反应单独诱导。它们是由细胞介导的过敏性接触反应产生的，最近已在AD患者中证明了对各种环境过敏原的接触敏感性。然而，IgE介导的皮肤超敏反应或迟发型超敏反应的各种环境过敏原在AD的病理作用没有得到充分的评价。它们已被单独研究，仅针对特定的过敏原。因此，我们进行了一项联合测试程序，包括放射性过敏原吸附试验，点刺，划痕斑贴试验的8个环境过敏原在97例日本成人AD患者，其中48例有过敏性呼吸道疾病（ARD）的历史，而其余49没有ARD（纯AD）的历史。
结果
AD患者，特别是ARD患者（AD+ARD），放射性过敏原吸附试验和点刺试验结果阳性以及多种环境过敏原斑贴试验结果阳性的发生率高于年龄匹配的健康对照受试者。其中，我们发现AD患者的放射性过敏原吸附试验评分和斑贴试验对两种过敏原（日本雪松和粉尘螨过敏原）的反应之间存在显著的正相关。然而，AD患者对白色念珠菌过敏原的斑贴试验阳性反应的发生率显著低于健康对照组。白念珠菌斑贴试验阴性的AD患者血清总IgE（包括抗白念珠菌IgE抗体）水平往往较高。我们发现血清总IgE水平，包括特异性抗体和斑贴试验反应白色念珠菌过敏原之间呈负相关。
结论
除了对白色念珠菌过敏原的解离反应性（包括接触敏感性降低和IgE反应升高）外，AD患者通常对IgE介导的皮肤超敏反应和对各种环境过敏原的迟发型超敏反应都很明显。这些在体内和体外试验的组合使用是有用的，以估计AD患者的免疫状态。
BACKGROUND AND DESIGN
Atopic dermatitis (AD) is a chronic eczematous skin disease that develops in a patient with atopic diathesis, which is characterized by an increased liability to produce IgE antibodies for environmental allergens mostly derived from other living organisms. Experimentally, eczematous skin lesions cannot be induced by immediate IgE-mediated reactions alone. They are produced by cell-mediated allergic contact reactions, and recently contact sensitivity to various environmental allergens has been demonstrated in patients with AD. However, the pathologic role of IgE-mediated skin hypersensitivity or that of delayed-type hypersensitivity to various environmental allergens in AD is not fully evaluated. They have been studied separately and against only specific allergens. Thus, we performed a combined testing procedure consisting of radioallergosorbent test, prick, and scarification patch tests for eight environmental allergens in 97 Japanese adult patients with AD; 48 of them had a history of atopic respiratory diseases (ARD), whereas the remaining 49 had no history of ARD (pure AD).
RESULTS
Patients with AD, particularly those with ARD (AD+ARD), showed a higher incidence of positive radioallergosorbent test and prick test results as well as patch test results against multiple environmental allergens than healthy age-matched control subjects. Among them, we found a significantly high positive correlation between radioallergosorbent test scores and patch test reactions to two allergens, Japanese cedar, and Dermatophagoides farinae allergens in patients with AD. However, the patients with AD displayed a significantly lower incidence of positive patch test reactions to Candida albicans allergen than the healthy control subjects. Patients with AD with negative C albicans patch tests tended to have higher levels of total serum IgE including anti-C albicans IgE antibody. We found negative correlations between total serum IgE levels including specific antibodies and patch test reactions to C albicans allergen.
CONCLUSIONS
Except for the dissociated reactivities to C albicans allergen consisting of decreased contact sensitivity and heightened IgE response, generally both IgE-mediated skin hypersensitivity and delayed-type hypersensitivity to various environmental allergens are pronounced in patients with AD. The combined use of these in vivo and in vitro tests is useful to estimate the immunological state of patients with AD.
影响因子：
4.4
作者：
T. Gajewski;F. Fitch
通讯作者：
T. Gajewski;F. Fitch
不产生白细胞介素 4 (IL 4)/B 细胞刺激因子 1 (BSF-1) 的克隆 Ia 限制性 T 细胞无法帮助抗原特异性 B 细胞。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Killar,L;MacDonald,G;West,J;Woods,A;Bottomly,K
通讯作者：
Bottomly,K