Epigenetics: New Concepts of Old Phenomena in Vascular Physiology
Epigenetics: New Concepts of Old Phenomena in Vascular Physiology
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DOI：
10.2174/157016109789043883
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发表时间：
2009-10-01
影响因子：
4.5
通讯作者：
Casanello, Paola
中科院分区：
文献类型：
--
作者：
Krause, Bernardo;Sobrevia, Luis;Casanello, Paola
“健康和疾病的发育起源”假说(DOHAD)依赖于胎儿发育过程中感知和发出不同刺激信号的机制的存在。被广泛认为参与这些过程的机制是表观遗传修饰，它可以‘记录’围产期的刺激。由于表观遗传及其相关机制的定义是相互矛盾的，在本文中，表观遗传被定义为“基于染色体的改变细胞或有机体表型可塑性的机制”。简要综述了表观遗传机制(DNA甲基化、组蛋白翻译后修饰(PTM)、依赖于ATP的染色质修饰和非编码RNA)及其在胎儿程序设计中作用的已报道证据。出于这个原因，血管细胞是关于表观遗传编程的很好的候选细胞，因为它被证明是易被印记的。这已经在妊娠疾病中得到了描述，如宫内生长受限、妊娠期糖尿病和先兆子痫，这些疾病中血管功能的变化在体外保存。
The hypothesis of 'Developmental Origins of Health and Disease' (DOHaD) relies on the presence of mechanisms sensing and signalling a diversity of stimuli during fetal development. The mechanisms that have been broadly suggested to be involved in these processes are the epigenetic modifications that could 'record' perinatal stimuli. Since the definition of epigenetic and the associated mechanisms are conflictive, in this review epigenetic was defined as 'chromosome-based mechanisms that can change the phenotypic plasticity in a cell or organism'. The most understood epigenetic mechanisms (i.e. DNA methylation, histone post-translational modifications (PTM), ATP-dependent chromatin modifications and non-coding RNAs) and reported evidence for their role in fetal programming were briefly reviewed.The development of the vascular system is strongly influenced by epigenetic mechanisms. For that reason vascular cells are good candidates to be explored regarding epigenetic programming since its proved susceptibility to be imprinted. This has been described in pregnancy diseases such as intra-uterine growth restriction, gestational diabetes and pre-eclampsia, where changes in vascular function are preserved in vitro.