Fabrication of nitric oxide-releasing polyurethane glucose sensor membranes
Fabrication of nitric oxide-releasing polyurethane glucose sensor membranes
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DOI：
10.1016/j.bios.2011.06.005
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发表时间：
2011-10-15
影响因子：
12.6
通讯作者：
Schoenfisch, Mark H.
中科院分区：
文献类型：
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作者：
Koh, Ahyeon;Riccio, Daniel A.;Schoenfisch, Mark H.
尽管有明确的证据表明，聚合物一氧化氮（NO）释放涂层减少异物反应（FBR），并因此可以提高分析性能的体内连续葡萄糖监测装置时，用作传感器膜，NO释放化学与酶促葡萄糖传感所需的兼容性仍然不清楚。在这里，我们描述了一氧化氮释放聚氨酯传感器膜的制造和表征使用一氧化氮供体改性的二氧化硅车辆嵌入聚合物。除了证明作为NO供体二氧化硅支架和聚合物组合物和浓度的函数的可调NO释放之外，我们描述了NO释放媒介物及其释放动力学对葡萄糖传感器性能的影响。(C)2011 Elsevier B.V.保留所有权利。
Despite clear evidence that polymeric nitric oxide (NO) release coatings reduce the foreign body response (FBR) and may thus improve the analytical performance of in vivo continuous glucose monitoring devices when used as sensor membranes, the compatibility of the NO release chemistry with that required for enzymatic glucose sensing remains unclear. Herein, we describe the fabrication and characterization of NO-releasing polyurethane sensor membranes using NO donor-modified silica vehicles embedded within the polymer. In addition to demonstrating tunable NO release as a function of the NO donor silica scaffold and polymer compositions and concentrations, we describe the impact of the NO release vehicle and its release kinetics on glucose sensor performance. (C) 2011 Elsevier B.V. All rights reserved.