Exploring the heterogeneity of white adipose tissue in mouse and man.
Exploring the heterogeneity of white adipose tissue in mouse and man.
复制标题
探索小鼠和人类白色脂肪组织的异质性。
DOI：
10.1016/j.gde.2023.102045
复制
发表时间：
2023
影响因子：
4
通讯作者：
Rosen,EvanD
中科院分区：
文献类型：
--
作者：
Emont,MargoP;Rosen,EvanD
HighlightsAdipose tissue is a heterogeneous organ that dynamically remodels in response to stimuli.Subtypes of white adipocytes have been identified using technologies like sNuc-seq.Subtypes may arise transcriptionally and/or due to transient signaling events.There may be a relationship between adipose subtypes and metabolic state.Adipose tissue is a heterogeneous organ, comprising cell types, including mature adipocytes, progenitor cells, immune cells, and vascular cells. Here, we discuss the heterogeneity of human and mouse white adipose tissue in general and white adipocytes specifically, focusing on how our understanding of adipocyte subpopulations has expanded with the advent of single nuclear RNA sequencing and spatial transcriptomics. Furthermore, we discuss critical remaining questions regarding how these distinct populations arise, how their functions differ from one another, and which potentially contribute to metabolic pathophysiology.
