Serum Dioxin Levels in Vietnamese Men more than 40 Years after Herbicide Spraying
Serum Dioxin Levels in Vietnamese Men more than 40 Years after Herbicide Spraying
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DOI：
10.1021/es404853h
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发表时间：
2014-03-18
影响因子：
11.4
通讯作者：
Le Ke Son
中科院分区：
文献类型：
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作者：
Ho Dung Manh;Kido, Teruhiko;Le Ke Son
最近的研究发现，美国在越南的一些前空军基地内二恶英水平升高，这些基地被称为热点地区。许多关于橙剂的研究都是在美国退伍军人身上进行的；然而，关于越南男性的研究知之甚少。2010年，我们在越南北部的一个热点地区采集了97名男性的血液样本，在一个未喷洒杀虫剂的地区采集了85名男性的血液样本。不仅TCDD，而且其他二恶英(PCDDs)、呋喃(PCDFs)和非邻位多氯联苯(PCbs)的血清浓度在热点地区显著高于未喷洒区域。在热点地区，根据与空军基地的距离划分了三个分区。多氯二苯并二恶英/多氯二苯并呋喃+多氯联苯的总毒性当量(TEQ)在最接近空军基地的区域为41.7pg/g脂肪，而在其他两个分区约为29pg/g脂肪。在未喷洒的地区，越南战争期间去过南方的人和留在北方的人的二恶英水平没有区别，TEQs、PCDDs/PCDFs+PCbs的水平约为13.6pg/g脂肪。我们的发现表明，居住在前美国空军基地附近的人可能同时接触了橙剂和其他来源的二恶英类化合物。
Recent studies have found elevated dioxin levels inside some U.S. military former air bases in Vietnam, known as hotspots. Many studies of Agent Orange have been done in U.S. veterans; however, there is little known about Vietnamese men. In 2010, we collected blood samples from 97 men in a hotspot and 85 men in an unsprayed area in Northern Vietnam. Serum concentrations of not only TCDD but also other dioxins (PCDDs), furans (PCDFs), and nonortho polychlorinated biphenyls (PCBs) were significantly higher in the hotspot than in the unsprayed area. In the hotspot, three subareas were demarcated, based on their proximity to the air base. The total toxic equivalents (TEQ) of PCDDs/PCDFs+PCBs was 41.7 pg/g lipid in the area closest to the air base, while it was around 29 pg/g lipid in the other two subareas. In the unsprayed area, the dioxin levels were no different between men who went to the South during the Vietnam War and those who remained in the North, with TEQs PCDDs/PCDFs+PCBs of around 13.6 pg/g lipid. Our findings suggested that people living close to the former U.S. air bases might have been exposed to both Agent Orange and other sources of dioxin-like compounds.