Schwann cells as a therapeutic target for peripheral neuropathies.
Schwann cells as a therapeutic target for peripheral neuropathies.
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DOI：
10.2174/187152710793237412
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Höke A
中科院分区：
文献类型：
--
作者：
Lehmann HC;Höke A
雪旺细胞是周围神经系统中的髓鞘形成细胞，在各种炎症性、代谢性和遗传性多发性神经病的病理过程中发挥着关键作用。在鉴定雪旺细胞表达的生长因子和信号分子方面的进展为开发新的治疗策略铺平了道路，旨在改善雪旺细胞在周围神经疾病中的保护和再生特性。其中包括生长因子和神经激素的外源性应用，它们已进入人类临床试验，以及已进入晚期临床前模型的移植范例。在这篇综述中，我们将讨论这些治疗方法的最新进展，特别是周围神经疾病，其中基础研究的进展已经转化为临床试验，包括HIV相关的远端感觉多发性神经病和糖尿病神经病变。
Schwann cells, the myelin forming cells in the peripheral nervous system, play a key role in the pathology of various inflammatory, metabolic and hereditary polyneuropathies. Advances in identifying growth factors and signaling molecules that are expressed by Schwann cells have paved the way to development of new treatment strategies that are aimed to improve the protective and regenerative properties of Schwann cells in peripheral nerve disorders. These include the exogenous application of growth factors and neurohormones, which have been advanced into clinical trials in humans and transplantation paradigms that have been moved into late stage preclinical models. In this review we will discuss the latest developments in these therapeutic approaches with special regard to peripheral nerve disorders, in which the progress in basic research have already been translated into clinical trials including HIV-associated distal sensory polyneuropathy and diabetic neuropathy.