Genes, suicide and decisions
Genes, suicide and decisions
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DOI：
10.1016/j.eurpsy.2009.12.010
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发表时间：
2010-06-01
影响因子：
7.8
通讯作者：
Jollanta, F.
中科院分区：
文献类型：
--
作者：
Courtet, P.;Guillaume, S.;Jollanta, F.
Objective. - 更好地了解自杀行为（SB）的病理生理学可能有助于发现更具体的治疗方法，并更好地识别易受伤害的患者。SB的脆弱性似乎是由遗传因素编码的特征，使个人能够科普压力的情况下，更有可能从事自杀的过程。- 近年来，神经科学研究开始确定潜在的内表型。- 我们已经证明，不利的决策（DM）参与了SB的脆弱性。DM损害似乎是独立的共病精神障碍，与情绪失调（即情感不稳定特征和皮肤电导反应），并受到与SB相关的血清素能基因型的调节。在最近的fMRI研究中，可能与DM相关的区域在对愤怒面孔的反应中过度活跃，表明对特定的负面社会刺激更敏感。风险评估的缺陷和对特定情绪刺激的过度反应可能是SB易感性的关键过程。- 这些潜在的内在表型可能代表未来的脆弱性相关标志物，用于识别脆弱患者，以及开发新治疗方法的相关目标。(C)2010年Elsevier Masson SAS。All rights reserved.
Objective. - A better understanding of the pathophysiology of suicidal behaviour (SB) may enable the discovery of more specific treatments and a better identification of vulnerable patients. The vulnerability to SB appears to be underlied by genetic factors coding for traits rendering the individual less able to cope with stressing situations, and more likely to be engaged in a suicidal process.Method. - During the recent years, neuroscientific studies begun to identify potential endophenotypes.Results. - We have shown that disadvantageous decision making (DM) was involved in the vulnerability to SB. DM impairment appears to be independent of comorbid psychiatric disorders, associated with emotional dysregulation (i.e. affective lability trait and skin conductance responses), and modulated by serotonergic genotypes associated with SB. In recent fMRI studies, the region that is likely involved in DM, is overactivited in response to angry faces, suggesting a higher sensitivity to specific negative social stimuli. Deficit in risk evaluation and excessive response to specific emotional stimuli may represent key processes in the vulnerability to SB.Conclusions. - These potential endophenotypes may represent future relevant markers of vulnerability for the identification of vulnerable patients, and relevant targets for the development of new treatments. (C) 2010 Elsevier Masson SAS. All rights reserved.