Early Oseltamivir After Hospital Admission Is Associated With Shortened Hospitalization: A 5-Year Analysis of Oseltamivir Timing and Clinical Outcomes
Early Oseltamivir After Hospital Admission Is Associated With Shortened Hospitalization: A 5-Year Analysis of Oseltamivir Timing and Clinical Outcomes
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DOI：
10.1093/cid/ciy860
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发表时间：
2019-07-01
影响因子：
11.8
通讯作者：
Ison, Michael G.
中科院分区：
文献类型：
--
作者：
Katzen, Jeremy;Kohn, Rachel;Ison, Michael G.
背景。神经氨酸酶抑制剂（NAIs）是治疗流感的唯一有效药物，但很少有研究评估早期NAI治疗对临床结果的影响或决定住院患者早期NAI递送的患者水平因素。我们对2009年4月至2014年3月期间在某大城市三级医院确诊流感住院的所有成年人进行了回顾性队列研究。我们进行了逻辑回归，以确定与早期NAI治疗相关的患者水平因素。我们分别使用线性和逻辑回归分析了早期NAI治疗与住院时间（LOS）和住院死亡率的关系。在5个流感季节，共有699名流感患者入院。其中582例（83.4%）接受了NAI治疗；然而，只有26.0%的患者在住院6小时内（早期NAI）接受了第一次剂量。合并糖尿病或妊娠的患者更容易发生早期NAI （P = 0.01, P = 0.05）
Background. Neuraminidase inhibitors (NAIs) are the only effective therapy for influenza, but few studies have assessed the impact of early NAI therapy on clinical outcomes or the patient-level factors that determine early NAI delivery in hospitalized patients.Methods. We conducted a retrospective cohort study of all adults hospitalized in a metropolitan tertiary care hospital with confirmed influenza from April 2009 to March 2014. We performed logistic regression to determine patient-level factors that were associated with early NAI therapy. We analyzed the association of early NAI therapy with hospital lengths of stay (LOS) and in-hospital mortality rates using linear and logistic regression, respectively.Results. In total, 699 patients were admitted with influenza during the 5 influenza seasons. Of those, 582 (83.4%) received NAI therapy; however, only 26.0% received the first dose within 6 hours of hospitalization (early NAI). Patients with diabetes mellitus or pregnancy were more likely to receive early NAI (P =.01, vs. P