Nickel-Catalyzed Cross-Coupling of Anisoles with Alkyl Grignard Reagents via C-O Bond Cleavage
Nickel-Catalyzed Cross-Coupling of Anisoles with Alkyl Grignard Reagents via C-O Bond Cleavage
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DOI：
10.1021/acs.orglett.5b02200
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发表时间：
2015-09-04
期刊：
影响因子：
5.2
通讯作者：
Chatani, Naoto
中科院分区：
文献类型：
--
作者：
Tobisu, Mamoru;Takahira, Tsuyoshi;Chatani, Naoto
已经开发了镍催化的甲氧基芳烃与烷基格氏试剂的交叉偶联，其涉及C（芳基）-OMe键的断裂。使用1，3-二环己基咪唑-2-亚基作为配体允许引入各种烷基，包括Me、Me 3SiCH 2、ArCH 2、金刚烷基和环丙基。该方法也可用于带有C（芳基）-OMe键的复杂分子的烷基化制备。
Nickel-catalyzed cross-coupling of methoxyarenes with alkyl Grignard reagents, which involves the cleavage of the C(aryl)-OMe bond, has been developed. The use of 1,3-dicyclohexylimidazol-2-ylidene as a ligand allows the introduction of a variety of alkyl groups, including Me, Me3SiCH2, ArCH2, adamantyl, and cyclopropyl. The method can also be used for the alkylative elaboration of complex molecules bearing a C(aryl)-OMe bond.