Understanding protein aggregation from the view of monomer dynamics.
Understanding protein aggregation from the view of monomer dynamics.
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DOI：
10.1039/c2mb25334h
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发表时间：
2013-01-27
影响因子：
--
通讯作者：
Lapidus LJ
中科院分区：
文献类型：
--
作者：
Lapidus LJ
近年来，人们对蛋白质聚集的复杂过程进行了大量的研究。这篇综述着眼于聚集的最早阶段，早在原纤维形成之前，原纤维是许多基于聚集的疾病的标志，并提出第一步是由单体的重新配置动力学控制的。当重新配置比双分子扩散快得多或慢得多时，聚集就慢，但当它们相似时，聚集就快。综述了该模型的实验证据，并讨论了小分子聚集抑制剂预防疾病的前景。
Much work in recent years has been devoted to understanding the complex process of protein aggregation. This review looks at the earliest stages of aggregation, long before the formation of fibrils that are the hallmark of many aggregation-based diseases, and proposes that the first steps are controlled by the reconfiguration dynamics of the monomer. When reconfiguration is much faster or much slower than bimolecular diffusion, then aggregation is slow, but when they are similar, aggregation is fast. The experimental evidence for this model is reviewed and the prospects for small molecule aggregation inhibitors to prevent disease are discussed.