Thermal model for optimization of vascular laser tissue soldering

Thermal model for optimization of vascular laser tissue soldering
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用于优化血管激光组织焊接的热模型

DOI:
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发表时间:
2010
影响因子:
2.8
通讯作者:
M. Frenz
M. Frenz
中科院分区:
物理与天体物理2区
文献类型:
--
作者:
S. Bogni;Oliver F. Stumpp;M. Reinert;M. Frenz

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激光组织焊接(LTS)是一种基于蛋白质热变性过程的有前景的组织融合技术。激光手术过程中融合组织的热损伤一直是一个重要且具有挑战性的问题。特别是在动脉血管的 LTS 中,应避免内皮的强烈加热,以尽量减少血栓形成的风险。精确了解激光照射期间容器壁内的温度分布是不可避免的。作者开发了一个有限元模型 (FEM) 来模拟 LTS 期间血管内的温度分布。温度测量用于验证和校准模型。测试了不同的参数,例如激光功率、焊料吸收系数、焊料层厚度、容器冷却以及连续与脉冲能量沉积,以阐明它们对焊点内温度分布的影响,从而减少进一步的动物实验量。采用高激光功率和高吸收焊料的脉冲照射可产生最佳效果。 (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA,魏因海姆)
Laser tissue soldering (LTS) is a promising technique for tissue fusion based on a heat‐denaturation process of proteins. Thermal damage of the fused tissue during the laser procedure has always been an important and challenging problem. Particularly in LTS of arterial blood vessels strong heating of the endothelium should be avoided to minimize the risk of thrombosis. A precise knowledge of the temperature distribution within the vessel wall during laser irradiation is inevitable. The authors developed a finite element model (FEM) to simulate the temperature distribution within blood vessels during LTS. Temperature measurements were used to verify and calibrate the model. Different parameters such as laser power, solder absorption coefficient, thickness of the solder layer, cooling of the vessel and continuous vs. pulsed energy deposition were tested to elucidate their impact on the temperature distribution within the soldering joint in order to reduce the amount of further animal experiments. A pulsed irradiation with high laser power and high absorbing solder yields the best results. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
DOI: 10.1016/0169-2607(95)01640-f
发表时间: 1995-07-01
影响因子: 6.1
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发表时间: 1997-11-01
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DOI: 10.3109/02656739109004981
发表时间: 1991
期刊: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
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作者:
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