Spatial reference memory in normal aging Fischer 344 × Brown Norway F1 hybrid rats.
Spatial reference memory in normal aging Fischer 344 × Brown Norway F1 hybrid rats.
复制标题
正常衰老 Fischer 344 × Brown 挪威 F1 杂交大鼠的空间参考记忆。
DOI：
10.1016/j.neurobiolaging.2014.06.030
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发表时间：
2015
影响因子：
4.2
通讯作者：
Nicolle,MichelleM
中科院分区：
文献类型：
--
作者：
McQuail,JosephA;Nicolle,MichelleM
相对于其他品系的衰老啮齿动物，Fischer 344 × Brown挪威 F1 (F344 × BN-F1) 杂交大鼠表现出更长的寿命和更好的健康状况；然而，很少有行为报告彻底评估 F344 × BN-F1 整个生命周期的认知能力。因此，本研究在莫里斯水迷宫中评估了 6、18、24 或 28 个月大的 F344 × BN-F1 大鼠的空间参考记忆。在 6 至 18 个月以及 18 至 24 个月之间观察到参考记忆减少。 28个月时，空间学习并不比24个月时差，但游泳速度明显变慢。可靠的个体差异显示，约 50% 的 24 至 28 个月大的大鼠表现与 6 个月大的大鼠相似，而其他大鼠则存在空间学习障碍。老年大鼠在日常训练中的学习能力受到损害，但训练期间的信息保留能力却没有受到损害。无论策略如何，年老的老鼠学会逃到平台上的速度也较慢。总之，这些数据阐明了衰老 F344 × BN-F1 大鼠认知能力下降的轨迹，并阐明了相关的行为参数。
Fischer 344 × Brown Norway F1 (F344 × BN-F1) hybrid rats express greater longevity with improved health relative to aging rodents of other strains; however, few behavioral reports have thoroughly evaluated cognition across the F344 × BN-F1 lifespan. Consequently, this study evaluated spatial reference memory in F344 × BN-F1 rats at 6, 18, 24, or 28 months of age in the Morris water maze. Reference memory decrements were observed between 6 and 18 months and 18 and 24 months. At 28 months, spatial learning was not worse than 24 months, but swim speed was significantly slower. Reliable individual differences revealed that ∼50% of 24- to 28-month-old rats performed similarly to 6 months, whereas others were spatial learning impaired. Aged rats were impaired at learning within daily training sessions but not impaired at retaining information between days of training. Aged rats were also slower to learn to escape onto the platform, regardless of strategy. In summary, these data clarify the trajectory of cognitive decline in aging F344 × BN-F1 rats and elucidate relevant behavioral parameters.