Cytoplasmic lipid droplets - Rediscovery of an old structure as a unique platform
Cytoplasmic lipid droplets - Rediscovery of an old structure as a unique platform
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DOI：
10.1196/annals.1377.010
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Ohsaki, Yuki
中科院分区：
文献类型：
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作者：
Fujimoto, Toyoshi;Ohsaki, Yuki
细胞质脂滴（LDs）几乎存在于任何一种细胞中。它们有一个由表面磷脂单层覆盖的脂酯核。ld和/或富含ld的亚细胞组分中存在许多与各种细胞功能相关的蛋白质，这表明ld是一个独立的细胞器，参与各种细胞活动。此外，最近的一项研究表明，ld是蛋白酶体和自噬途径汇合的平台。本文讨论了ld的分子组成和结构，特别提到了分析这种独特细胞器时遇到的技术困难。
Cytoplasmic lipid droplets (LDs) exist in virtually any kind of cell. They have a core of lipid esters covered by the surface phospholipid monolayer. A number of proteins related to various cell functions are present in LDs and/or LD-rich subcellular fractions, suggesting that LDs are an independent organelle that is engaged in various cellular activities. Furthermore, a recent study suggested that LDs are a platform where the proteasomal and autophagic pathways converge. The molecular composition and architecture of LDs are discussed here, with special reference to the technical difficulties encountered when analyzing this unique organelle.