Typing of pneumococcal surface protein A (PspA) in Streptococcus pneumoniae isolated during epidemiological surveillance in Brazil:: towards novel pneumococcal protein vaccines
Typing of pneumococcal surface protein A (PspA) in Streptococcus pneumoniae isolated during epidemiological surveillance in Brazil:: towards novel pneumococcal protein vaccines
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DOI：
10.1016/j.vaccine.2004.04.009
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发表时间：
2004-09-28
期刊：
影响因子：
5.5
通讯作者：
Hollingshead, SK
中科院分区：
文献类型：
--
作者：
Brandileone, MCC;Andrade, ALSS;Hollingshead, SK
基于肺炎球菌表面蛋白A（PspA）的肺炎球菌蛋白疫苗正在开发中，具有针对不同菌株提供广泛保护的潜力。我们已经调查了频率PspA家族I（Fam1）和家族2（Fam2）蛋白之间的肺炎链球菌正在进行的监测在巴西恢复。Fam I和Fam 2在366株分离株中的表达率相当，潜在覆盖率为94.3%。PspA家族与年龄组或分离株来源无关。然而，考虑到与遗传相关耐药菌株的广泛传播相关的Fam2流行率增加的显著趋势，在疫苗开发的背景下，可能需要监测来自基于人群的数据的PspA家族。(C)2004爱思唯尔有限公司保留所有权利。
Pneumococcal protein vaccine based on pneumococcal surface protein A (PspA) is in development with the potential to offer broad range of protection against different strains. We have investigated the frequency of PspA family I (Fam1) and family 2 (Fam2) proteins among Streptococcus pneumoniae recovered from ongoing surveillance in Brazil. Fam I and Fam2 were expressed in comparable rates among 366 isolates, with the potential coverage of 94.3%. PspA families were not associated to age group or source of isolates. However, considering the significant tendency of increasing prevalence of Fam2 associated to widespread dissemination of the genetically-related resistant strains, the monitoring of the PspA families derived from population-based data may be necessary in the context of vaccine development. (C) 2004 Elsevier Ltd. All rights reserved.