Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats.
Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats.
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DOI：
10.1186/s13098-015-0109-1
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发表时间：
2015
影响因子：
4.8
通讯作者：
De Angelis K
中科院分区：
文献类型：
--
作者：
Freitas SC;Harthmann Âd;Rodrigues B;Irigoyen MC;De Angelis K
高血糖与各个器官的血流量减少有关，导致组织损伤和功能障碍。众所周知，运动训练（ET）可以促进自主神经系统的有益变化，并可能对血液循环产生影响。本研究的目的是评估糖尿病大鼠 ET 后的冠状动脉和肾血流量以及血管阻力。 32 只大鼠被分为四组 (n = 8)：久坐对照组 (SC)、训练对照组 (TC)、久坐糖尿病组 (SD)、训练糖尿病组 (TD)。注射链脲佐菌素（STZ，50 毫克/千克）诱发糖尿病。 ET 在跑步机上进行了 10 周。使用有色微球测量血流量。糖尿病组出现高血糖（血糖 >350 mg/dL），ET 并未改变该参数。与 SC 组相比，SD 组肾血流量减少，ET 能够使 TD 大鼠的该参数正常化（SC：4.3 ± 0.5；TC：2.9 ± 0.3；SD：1.9 ± 0.4；TD：3.2 ± 0.4 mL/min/g）。 TD 组与 SD 组相比，冠状动脉血流量增加（SC：2.3 ± 0.23；TC：2.8 ± 0.5；SD：1.2 ± 0.4；TD：3.0 ± 0.4 mL/min/g）。与SC组相比，SD组的心脏和肾脏血管阻力增加，而ET能够逆转这些变化。鉴于心肌病和肾病与糖尿病患者死亡率的相关性，我们的结果表明，ET 可有效改善 STZ 糖尿病大鼠的冠状动脉和肾血流量以及血管阻力，强化了该方法在预防高血糖引起的长期器官损伤方面的积极作用。
Hyperglycemia has been associated with decreased blood flow in various organs, leading to tissue damage and dysfunctions. Exercise training (ET) is known to promote beneficial changes in the autonomic nervous system and may have effects on circulation. The aim of this study was to evaluate coronary and renal blood flows and vascular resistances after ET in diabetic rats. Thirty-two rats were divided into four groups (n = 8): sedentary control (SC), trained control (TC), sedentary diabetic (SD), trained diabetic (TD). Diabetes was induced by an injection of streptozotocin (STZ, 50 mg/kg). The ET was performed on a treadmill for 10 weeks. The blood flows were measured using colored microspheres. The diabetic groups presented hyperglycemia (blood glucose >350 mg/dL) and ET did not change this parameter. The SD group showed reduced renal blood flow when compared to SC group, and ET was able to normalize this parameter in TD rats (SC: 4.3 ± 0.5; TC: 2.9 ± 0.3; SD: 1.9 ± 0.4; TD: 3.2 ± 0.4 mL/min/g). TD group presented increased coronary blood flow in relation to SD group (SC: 2.3 ± 0.23; TC: 2.8 ± 0.5; SD: 1.2 ± 0.4; TD: 3.0 ± 0.4 mL/min/g). The heart and kidneys vascular resistance were increased in SD group when compared to SC group, and ET was able to reverse these changes. Given the relevance of cardiomyopathy and nephropathy in mortality of diabetics, our results demonstrated that ET is effective in improving coronary and renal blood flows and vascular resistances in STZ-diabetic rats, reinforcing the positive role of this approach in preventing hyperglycemia-induced long-term organ damage.