Soft drugs V: Thiazolidine-type derivatives of progesterone and testosterone.
Soft drugs V: Thiazolidine-type derivatives of progesterone and testosterone.
复制标题
软性药物V：黄体酮和睾酮的噻唑烷型衍生物。
DOI：
10.1002/jps.2600710509
复制
发表时间：
1982
影响因子：
3.8
通讯作者：
K. Sloan
中科院分区：
文献类型：
--
作者：
N. Bodor;K. Sloan
Progesterone and testosterone are natural soft drugs, but to be used as drugs, their fast and facile metabolism must be prevented and their delivery controlled. A prodrug-soft drug combination can serve this purpose. Thiazolidines of testosterone, testosterone 17-propionate and progesterone were synthesized from the reaction of cysteine alkyl esters, N-methylaminoethanethiol, and mercaptamine and their hydrochlorides with the appropriate steroids. The thiazolidines function as bioreversible derivatives of the parent steroids.
