LRP-1: functions, signaling and implications in kidney and other diseases.
LRP-1: functions, signaling and implications in kidney and other diseases.
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DOI：
10.3390/ijms151222887
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发表时间：
2014-12-10
影响因子：
5.6
通讯作者：
Hu K
中科院分区：
文献类型：
--
作者：
Lin L;Hu K
低密度脂蛋白（LDL）相关蛋白-1（LRP-1）是LDL受体家族的成员，参与脂蛋白代谢和蛋白酶及蛋白酶抑制剂的稳态。LRP-1的表达是普遍存在的。LRP-1的上调已在许多人类疾病中报道。除了其作为各种配体的清道夫受体的功能之外，LRP-1已被证明可以调节多种细胞内信号通路，包括促分裂原活化蛋白激酶（MAPK）、Akt、Rho和整联蛋白信号传导。LRP-1信号在细胞增殖、存活、运动、分化和转分化等多种细胞过程的调节中发挥重要作用，从而参与器官功能障碍和损伤的发病机制。本文就LRP-1信号通路及其在肾脏疾病发生、发展中的作用作一综述。LRP-1在神经和心血管系统中的作用和信号传导，以及在致癌作用中，也进行了简要讨论。
Low-density lipoprotein (LDL)-related protein-1 (LRP-1) is a member of LDL receptor family that is implicated in lipoprotein metabolism and in the homeostasis of proteases and protease inhibitors. Expression of LRP-1 is ubiquitous. Up-regulation of LRP-1 has been reported in numerous human diseases. In addition to its function as a scavenger receptor for various ligands, LRP-1 has been shown to transduce multiple intracellular signal pathways including mitogen-activated protein kinase (MAPK), Akt, Rho, and the integrin signaling. LRP-1 signaling plays an important role in the regulation of diverse cellular process, such as cell proliferation, survival, motility, differentiation, and transdifferentiation, and thus participates in the pathogenesis of organ dysfunction and injury. In this review, we focus on the current understanding of LRP-1 signaling and its roles in the development and progression of kidney disease. The role and signaling of LRP-1 in the nervous and cardiovascular systems, as well as in carcinogenesis, are also briefly discussed.
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影响因子：
3.7
作者：
Gopal U;Bohonowych JE;Lema-Tome C;Liu A;Garrett-Mayer E;Wang B;Isaacs JS
通讯作者：
Isaacs JS
影响因子：
3.7
作者：
Boucher, Philippe;Li, Wei-Ping;Matz, Rachel L.;Takayama, Yoshiharu;Auwerx, Johan;Anderson, Richard G. W.;Herz, Joachim
通讯作者：
Herz, Joachim
影响因子：
7.4
作者：
Cal R;Juan-Babot O;Brossa V;Roura S;Gálvez-Montón C;Portoles M;Rivera M;Cinca J;Badimon L;Llorente-Cortés V
通讯作者：
Llorente-Cortés V
影响因子：
4.8
作者：
Barnes, H;Larsen, B;van der Geer, P
通讯作者：
van der Geer, P
DOI：
10.1073/pnas.89.16.7427
发表时间：
1992-08-15
影响因子：
11.1
作者：
BU, GJ;WILLIAMS, S;SCHWARTZ, AL
通讯作者：
SCHWARTZ, AL