Mechanisms of lesion formation in high intensity focused ultrasound therapy
Mechanisms of lesion formation in high intensity focused ultrasound therapy
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DOI：
10.1121/1.1559911
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发表时间：
2003-04-01
期刊：
影响因子：
--
通讯作者：
Crum, LA
中科院分区：
文献类型：
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作者：
Chen, WS;Lafon, C;Crum, LA
高强度超声产生的病变进行了研究，在透明的组织幻影预混超声造影剂（UCA）在1.1和3.5 MHz的声波。在曝光的最开始就观察到小气泡的产生，而雪茄形的热损伤在延迟后开始在焦点处形成。在进一步加热后，发生沸腾，并将病变改变为蝌蚪形，并向换能器推进。UCA在体模中检测到宽带噪声。UCA还降低了压力阈值并扩大了病变。虽然热效应和空化效应被认为在损伤形成中都是重要的，但蝌蚪形转化是由沸腾活动引起的。(C)2003年，美国声学学会。
The lesions generated by high intensity ultrasound were studied in transparent tissue phantoms premixed with and without ultrasound contrast agents (UCA) at 1.1- and 3.5-MHz acoustic waves. Generation of small bubbles was observed at the very beginning of exposure, whereas cigar-shaped thermal lesions began to form at the focus after a delay. After further heating, boiling occurred and changed the lesion to tadpole-shape, with advancement toward the transducer. Broadband noise was detected in phantoms with UCA initially. UCA also lowered the pressure threshold and enlarged the lesion. Although thermal and cavitation effects are believed to be both important in lesion formation, tadpole-shaped transformation results from boiling activity. (C) 2003 Acoustical Society of America.