Profiles of m6A RNA methylation regulators for the prognosis of hepatocellular carcinoma
Profiles of m6A RNA methylation regulators for the prognosis of hepatocellular carcinoma
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m(6)A RNA 甲基化调节因子对肝细胞癌预后的影响
DOI：
10.3892/ol.2020.11435
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发表时间：
2020-04-01
期刊：
影响因子：
2.9
通讯作者：
Wu, Peihong
中科院分区：
文献类型：
--
作者：
Li, Wang;Chen, Qi-Feng;Wu, Peihong
N6-甲基腺苷（M（6）A）RNA甲基化与癌症的启动和进展有关，由M（6）A RNA甲基化调节剂（包括“作者”，“擦除者”和“读者”）动态调节。然而，M（6）涉及肝细胞癌（HCC）癌变和进展的RNA甲基化调节剂的预后值尚待阐明。本研究的目的是确定基于这些调节剂的HCC患者预后的预后评分。在癌症基因组地图集中，发现13个主要M（6）中的大多数RNA甲基化调节剂在HCC和正常样品之间差异表达（P
N6-methyladenosine (m(6)A) RNA methylation, which is related to cancer initiation and progression, is dynamically regulated by the m(6)A RNA methylation regulators (including 'writers', 'erasers' and 'readers'). However, the prognostic value of m(6)A RNA methylation regulators involved in hepatocellular carcinoma (HCC) carcinogenesis and progression remains to be elucidated. The aim of the present study was to determine the prognostic score in predicting the prognosis of HCC patients based on these regulators. In The Cancer Genome Atlas, most of the 13 major m(6)A RNA methylation regulators were found to be differentially expressed between HCC and normal samples (P