BIOLOGIC CLOCK - MITOCHONDRIA
BIOLOGIC CLOCK - MITOCHONDRIA
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DOI：
10.1111/j.1532-5415.1972.tb00787.x
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发表时间：
1972-01-01
影响因子：
6.3
通讯作者：
HARMAN, D
中科院分区：
文献类型：
--
作者：
HARMAN, D
作者认为，特定哺乳动物物种的最长寿命在很大程度上是对氧气利用率的遗传控制的表现。后者决定了自由基反应产生的线粒体损伤的累积速度，该速度随着氧气消耗速度的增加而增加，最终导致死亡。
The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen consumption, which ultimately causes death.