0.5 M Gd chelate (Magnevist®) versus 1.0 M Gd chelate (Gadovist®):: Dose-independent effect on image quality of pelvic three-dimensional MR-angiography
0.5 M Gd chelate (Magnevist®) versus 1.0 M Gd chelate (Gadovist®):: Dose-independent effect on image quality of pelvic three-dimensional MR-angiography
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DOI：
10.1002/jmri.1225
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发表时间：
2001-11-01
影响因子：
4.4
通讯作者：
Ruehm, SG
中科院分区：
文献类型：
--
作者：
Goyen, M;Lauenstein, TC;Ruehm, SG
为了比较 1.0 M 钆 (Gd) 螯合物与传统 0.5 M Gd 螯合物对图像质量的影响，五名健康志愿者和七名患有血管造影记录的主动脉髂疾病的患者接受了两次单站三维磁共振血管造影 (MRA) 检查（德国埃尔兰根的西门子 SONATA(R)），一次使用 Gadovist(R) 1.0，另一次使用Magnevist(R) 作为造影剂。所有受试者均接受固定体积的 Gadovist(R) 1.0，相当于 0.1 至 0.15 mmol/kg 体重的剂量，然后用生理盐水冲洗。对于 Magnevist(R) 检查，造影剂体积和流速加倍。为了对血管造影数据集进行定量和定性分析，动脉树被分为九段。与 0.5 M Magnevist(R) 增强图像相比，1 M Gadovist(R) 1.0 增强三维 MRA 数据集的信噪比 (SNR) 和对比度噪声比 (CNR) 值明显更高。数据显示平均 SNR/CNR 增加超过 70% (P < 0.01)。尽管图像质量评级没有统计学上的显着差异（P > 0.05），但Gadovist(R) 1.0 检查可以更好地描绘动脉形态，尤其是小血管。 (C) 2001 Wiley-Liss, Inc.
To compare the effect on image quality of a 1.0 M gadolinium (Gd) chelate to that of a conventional 0.5 M Gd chelate, five healthy volunteers and seven patients with angiographically documented aorto-iliac disease underwent a mono-station three-dimensional magnetic resonance angiography (MRA) exam (Siemens SONATA(R), Erlangen, Germany) twice, once using Gadovist(R) 1.0 and the other time using Magnevist(R) as the contrast agent. All subjects received a fixed volume of Gadovist(R) 1.0, corresponding to a dose between 0.1 and 0.15 mmol/kg body weight followed by a saline flush. For the Magnevist(R), exam, the contrast agent volumes and flow rates were doubled. For both quantitative and qualitative analysis of the angiographic data sets, the arterial tree was divided into nine segments. 1 M Gadovist(R) 1.0-enhanced three-dimensional MRA data sets were characterized by significantly higher signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) values compared to 0.5 M Magnevist(R)-enhanced images. The data revealed mean SNR/CNR increases exceeding 70% (P < 0.01). Although there was no statistically significant difference in the rating of image quality (P > 0.05), the Gadovist(R) 1.0 exam led to better delineation of the arterial morphology, especially of small vessels. (C) 2001 Wiley-Liss, Inc.