Biomarkers of diseases in medicine

Biomarkers of diseases in medicine
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医学疾病的生物标志物

DOI:
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发表时间:
2009
期刊:
影响因子:
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通讯作者:
S. Sarin
S. Sarin
中科院分区:
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文献类型:
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作者:
Manoj Kumar;S. Sarin

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生物标志物在医学实践中获得了巨大的科学和临床价值和兴趣。生物标记物在疾病过程的整个光谱中都有潜在的作用。在诊断前,可以使用标志物进行筛查和风险评估。在诊断过程中,标记物可以决定分期、分级和初始治疗的选择。在治疗期间,它们可用于监测治疗、选择额外治疗或监测复发疾病。基因组学、蛋白质组学和分子病理学的进展产生了许多具有潜在临床价值的候选生物标志物。在未来,将使用新兴的高通量技术确定的生物标记物整合到医疗实践中,以实现治疗和疾病预防的“个性化”。
Biomarkers have gained immense scientific and clinical value and interest in the practise of medicine. Biomarkers are potentially useful along the whole spectrum of the disease process. Before diagnosis, markers could be used for screening and risk assessment. During diagnosis, markers can determine staging, grading, and selection of initial therapy. During treatment, they can be used to monitor therapy, select additional therapy, or monitor recurrent diseases. Advances in genomics, proteomics and molecular pathology have generated many candidate biomarkers with potential clinical value. In the future, integration of biomarkers, identified using emerging high-throughput technologies, into medical practise will be necessary to achieve ‘personalization’ of treatment and disease prevention.
DOI: 10.1161/01.cir.97.18.1837
发表时间: 1998-05-12
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影响因子: 37.8
作者:
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