Adult or perinatal brain injury - Does sex matter?
Adult or perinatal brain injury - Does sex matter?
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DOI：
10.1161/01.str.0000153064.41332.f6
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发表时间：
2005-02-01
期刊：
影响因子：
8.3
通讯作者：
Hagberg, H
中科院分区：
文献类型：
--
作者：
Hurn, PD;Vannucci, SJ;Hagberg, H
复苏24-25然而，在敲除雌性中或在用特异性PARP抑制剂处理的野生型雌性中，PARP-1活性的丧失极大地加剧了缺血性损伤（图1）。[20]尽管目前尚不清楚这些细胞死亡途径在男性和女性中是如何分化的，但这些数据表明，性别可以改变脑损伤的分子背景。
recovery. 24–25 However, loss of PARP-1 activity in female knockouts, or in wild-type females treated with specific PARP inhibitors, hugely exacerbates ischemic damage (Figure 1). 20 Although it is not clear how these cell death pathways diverge in the male and female, these data suggest that sex can alter the molecular context of brain injury.