Adipokines in adolescence; the associations with lung function and atopy - A cross-sectional study.
Adipokines in adolescence; the associations with lung function and atopy - A cross-sectional study.
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青春期的脂肪因子；
DOI：
10.1016/j.rmed.2020.106063
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发表时间：
2020
影响因子：
4.3
通讯作者：
Øymar,Knut
中科院分区：
文献类型：
--
作者：
Mikalsen,IngvildBruun;Byberg,Kristine;Forman,MicheleR;Øymar,Knut
炎症和机械效应都被提出来解释在肥胖儿童和成人中观察到的哮喘风险增加和肺功能降低。关于肥胖在特应性和变态反应病因学中的潜在作用的证据更是相互矛盾。脂肪因子瘦素和脂联素是脂肪代谢的炎症标志物，可能参与解释肥胖儿童和成人哮喘风险增加和肺功能降低。在这项横断面研究中，我们的目的是研究脂联素和瘦素如何与青少年肺功能和特应性过敏相关，该研究包括384名儿童，平均年龄12.9岁，测量脂联素，瘦素，肺功能和特应性过敏。测定血清脂联素和瘦素水平，肺功能测定肺功能，特应性过敏测定血清特异性免疫球蛋白E。在线性回归模型中，瘦素与用力肺活量（FVC）呈负相关。（Beta：−4.13; 95%置信区间：−5.83，−2.44，P < 0.001）和第一秒用力呼气量（FEV 1）（−3.74; −5.39，−2.09，P < 0.001），调整体重指数（BMI）和其他协变量后。脂联素和肺功能之间或瘦素或脂联素和过敏性situation.In青少年在所有体重阶层的横断面分析，瘦素与FEV 1和FVC呈负相关，独立于BMI，但没有发现脂联素和肺功能之间的关联。结果表明，瘦素可能在健康儿童的气道中发挥功能性作用。
Both inflammatory and mechanical effects have been proposed to explain the increased risk of asthma and reduced lung function observed in obese children and adults. The evidence regarding the potential role of obesity in the aetiology of atopy and allergy is more conflicting. The adipokines leptin and adiponectin are inflammatory markers of fat metabolism which may be involved in explaining the increased risk of asthma and reduced lung function in obese children and adults. In this cross-sectional study, we aimed to study how adiponectin and leptin were associated with lung function and atopic sensitisation in adolescents.The study included 384 children at mean age 12.9 years with measurements of adiponectin, leptin, lung function and atopic sensitisation. Adiponectin and leptin levels were measured in serum, lung function was measured by spirometry and atopic sensitisation was measured by serum specific Immunoglobulin E.In linear regression models, leptin was negatively associated with forced vital capacity (FVC) (Beta: −4.13; 95% Confidence Interval: −5.83, −2.44, P < 0.001) and forced expiratory volume in the first second (FEV1) (−3.74; −5.39, −2.09, P < 0.001) after adjusting for body mass index (BMI) and other covariates. No associations were observed between adiponectin and lung function or between leptin or adiponectin and atopic sensitisation.In this cross-sectional analysis of adolescents in all weight classes, leptin was negatively associated with FEV1and FVC independent of BMI, but no associations were found between adiponectin and lung function. The results suggest that leptin may have a functional role in the airways of healthy children.