HIGH-FREQUENCY OF SILENT INFLAMMATORY BOWEL-DISEASE IN SPONDYLARTHROPATHY
HIGH-FREQUENCY OF SILENT INFLAMMATORY BOWEL-DISEASE IN SPONDYLARTHROPATHY
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DOI：
10.1002/art.1780370105
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发表时间：
1994-01-01
影响因子：
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通讯作者：
SEPPALA, K
中科院分区：
文献类型：
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作者：
LEIRISALOREPO, M;TURUNEN, U;SEPPALA, K
目标。寻找肠道感染、肠道炎症和脊柱关节病之间的联系。方法：研究方法。对118例各种炎症性和非炎症性关节疾病患者和24例无并发症的急性细菌性胃肠炎患者进行了回肠结肠镜检查。结果。与其他炎性关节炎患者(6%；P=0.001)相比，脊椎关节病患者的内窥镜病变更常见(44%)。回肠改变仅见于脊椎病患者(20%vs0%；P=0.01)。19%的关节炎患者的内窥镜诊断为炎症性肠病。26%的慢性脊椎关节病患者可能或明确诊断为克罗恩病，1例类风湿关节炎患者和1例慢性尿路关节炎患者诊断为溃疡性结肠炎。炎症的组织学证据在不同患者组之间的差异不如内窥镜检查所见明显。肠道损害与非类固醇抗炎药的使用或人类白细胞抗原B27的存在无关。结论。脊椎关节病患者的肠道炎症很常见，四分之一的慢性病患者具有克罗恩病的早期特征。
Objective. To search for an association between gut infection, gut inflammation, and spondylarthropathies. Methods. Ileocolonoscopy was performed in 118 patients with various inflammatory and noninflammatory joint diseases and in 24 patients with uncomplicated acute bacterial gastroenteritis. Results. Endoscopic lesions were more frequent in patients with spondylarthropathy (44%) compared with those with other inflammatory arthritides (6%; P = 0.001). Ileal changes were observed only in patients with spondylarthropathy (20% versus 0%; P = 0.01). Inflammatory bowel disease was the endoscopic diagnosis in 19% of the arthritis patients. Possible or definite Crohn's disease was diagnosed in 26% of patients with chronic spondylarthropathy, and ulcerative colitis in 1 patient with rheumatoid arthritis and in 1 with chronic uroarthritis. Histologic evidence of inflammation differed less distinctly than endoscopy findings between patient groups. There was no association of gut lesions with the use of nonsteroidal antiinflammatory drugs or with the presence of HLA-B27. Conclusion. Gut inflammation is frequent in patients with spondylarthropathy, and one-fourth of the patients who have chronic disease have early features of Crohn's disease.